Fogg P, Das K R, Kron T, Fox C, Chua B, Hagekyriakou J
Physical Sciences Department, Peter MacCallum Cancer Centre, Melbourne, Australia.
Australas Phys Eng Sci Med. 2010 Jun;33(2):211-4. doi: 10.1007/s13246-010-0019-3. Epub 2010 Jul 9.
Dosimetry for intraoperative radiotherapy (IORT) after wide local excision for breast cancer using a 50 kV X-ray needle (Intrabeam) was performed in vivo using thermoluminescence dosimetry. Eight LiF:Mg,Ti chips were placed on the skin around the incision site after wide local excision while the tumour bed was irradiated to a prescribed dose of 5 Gy 10 mm from the applicator surface. The maximum and mean measured skin dose for 57 patients ranged from 0.64 to 7.1 Gy and 0.56 to 4.78 Gy, respectively, reflecting different tissue thicknesses overlying the applicator. The average maximum dose of 2.93+/-1.46 Gy was below the threshold for severe radiation skin toxicity.
采用热释光剂量测定法对50 kV X射线针（Intrabeam）用于乳腺癌广泛局部切除术后术中放疗（IORT）进行体内剂量测定。在广泛局部切除术后，将八片LiF:Mg,Ti芯片置于切口部位周围的皮肤上，同时将肿瘤床从施源器表面10毫米处照射至规定剂量5 Gy。57例患者的最大和平均测量皮肤剂量分别为0.64至7.1 Gy和0.56至4.78 Gy，反映了施源器上方不同的组织厚度。平均最大剂量2.93±1.46 Gy低于严重放射性皮肤毒性阈值。
