Department of Chemistry, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, A1B3X7, Canada.
J Nat Prod. 2010 Aug 27;73(8):1427-30. doi: 10.1021/np1001169.
Enantioselective total syntheses and X-ray structures of both (S)-tetrahydropalmatrubine (2) and (S)-corytenchine (3) are reported for the first time. They were both derived from (S)-N-norlaudanidine, a benzyltetrahydroisoquinoline that was synthesized with high (>95% ee) enantioselectivity using a chiral auxiliary-assisted Bischler-Napieralski cyclization/reduction approach.
首次报道了（S）-四氢巴马汀（2）和（S）-考利藤宁（3）的对映选择性全合成和 X 射线结构。它们均由（S）-N-去甲劳丹碱衍生而来，这是一种苯甲基四氢异喹啉，通过使用手性辅助剂辅助的 Bischler-Napieralski 环化/还原方法以高（>95%ee）对映选择性合成。
