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1例具有部分21-羟化酶缺乏类固醇特征的男性化肾上腺皮质腺瘤(作者译)

[A case of virilizing adrenal cortical adenoma whose steroid profile evokes a partial 21-hydroxylase deficiency (author's transl)].

作者信息

Linck-Dubost M, Rifle C, Begue R J, Padieu P, Putelat R

出版信息

Ann Endocrinol (Paris). 1977;38(6):397-8.

PMID:206181
Abstract

The C19 and C21 urinary steroids from a virilizing adrenal tumour with high levels of plasma 17 alpha-hydroxyprogesterone and its urinary metabolites have been identified and quantitated gas chromatography and mass spectrometry of sephadex fractions of the total urinary extract. A of the fifty-five identified steroids thirteen were compounds not found before in such a case. The actiology of the apparent 21-steroid hydroxtlase deficiency is discussed at the light of these analytical results and of the hormonogenesis enzymatic induction of the tumour biopsy.

摘要

对一例具有高水平血浆17α-羟孕酮及其尿代谢产物的男性化肾上腺肿瘤的C19和C21尿甾体进行了鉴定和定量,采用气相色谱法和质谱法对总尿提取物的葡聚糖凝胶级分进行分析。在鉴定出的55种甾体中,有13种是此前在此类病例中未发现的化合物。根据这些分析结果以及肿瘤活检的激素生成酶诱导情况,对明显的21-甾体羟化酶缺乏的病因进行了讨论。

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