Warnakulasuriya K A, Samaranayake L P, Peiris J S
Department of Oral Medicine, University of Peradeniya, School of Dentistry, Sri Lanka.
J Oral Pathol Med. 1991 Apr;20(4):172-5. doi: 10.1111/j.1600-0714.1991.tb00915.x.
The relative importance of various factors in the pathogenesis of angular cheilitis in a population of Sri Lankan adults was studied. Forty-nine patients with cheilitis were examined clinically and microbiologically. Only 5 of 49 patients were full denture wearers. The clinical presentation of the lesions could be categorized as mild (Type I), moderate (Type II) or severe (Type III) and the duration of the lesions ranged from 1 month to more than 4 yr. Hematologic investigations revealed 18 patients with low hemoglobin 8 of whom had hypochromic, microcytic anaemia. Pathogenic organisms were isolated from 59% of the lesions; Candida spp. in 24 patients and Staph. aureus in 11 patients. A significant positive relationship between commissural leukoplakia and an infective etiology of angles was noted. This study confirms the multifactorial etiology of angular cheilitis while highlighting the varied clinical presentation of the lesions in an Asian population.
我们研究了斯里兰卡成年人群中各种因素在口角炎发病机制中的相对重要性。对49例唇炎患者进行了临床和微生物学检查。49例患者中只有5例佩戴全口假牙。病变的临床表现可分为轻度（I型）、中度（II型）或重度（III型），病变持续时间从1个月到4年以上不等。血液学检查发现18例患者血红蛋白偏低，其中8例为低色素小细胞性贫血。59%的病变部位分离出了致病微生物；24例患者分离出念珠菌属，11例患者分离出金黄色葡萄球菌。观察到口角白斑与口角感染性病因之间存在显著的正相关关系。本研究证实了口角炎的多因素病因，同时突出了亚洲人群中病变的多样临床表现。
