Riabov G A, Pasechnik I N
Khirurgiia (Mosk). 1991 Apr(4):120-3.
A method for the prevention of thrombotic complications with heparin was developed during examination of 30 elderly and old-aged patients who underwent operation for gastric carcinoma. It was established that the therapeutic activity of heparin in plasma is maintained for 6 hours after a single subcutaneous injection of 5,000 u. Four injections of this dose of heparin ensures its continuous therapeutic activity for 24 hours in elderly oncological patients. Heparin prevention in a daily dose of 20,000 u is safe from the standpoint of hemorrhagic complications. Under clinical conditions, control of plasma heparin activity may be accomplished by means of activated partial thromboplastin time.
在对30例接受胃癌手术的老年和高龄患者进行检查期间，开发了一种用肝素预防血栓形成并发症的方法。已确定，单次皮下注射5000单位肝素后，血浆中肝素的治疗活性可维持6小时。对老年肿瘤患者，四次注射该剂量的肝素可确保其24小时持续治疗活性。从出血并发症的角度来看，每日20000单位的肝素预防剂量是安全的。在临床条件下，可通过活化部分凝血活酶时间来控制血浆肝素活性。
