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[糖尿病足感染的微生物学调查]

[Microbiological investigation of diabetic foot infections].

作者信息

Chikviladze D, Gachechiladze Kh, Mikeladze M, Metreveli D, Avazashvili D

出版信息

Georgian Med News. 2010 Jun(183):22-6.

Abstract

The aim of the article was to determine the structure of infections agents in diabetic foot infections and their sensibility to antibiotics A total of 295 microbial isolates were obtained from 115 patients with confirmed diabetic foot infection, treated in 2005-2009 years. Of these aerobes were found in 92.88%, anaerobes - in 7.12%. Microbal associations, various aerbal bacteria were found in 58,49% of cases, associations of aerobes with anaerobes - in 17.92% of cases; from 21.70% of patients were isolated microbial monocultures. The most common gram positive infect in diabetic foot infection was S. aureus, gram negative - P. aeroginosa. Methicillinresistent S. aureus were - 57,52%. In 95.57% of cases S. aureus strains were sensitive to vancomicin. Strains of P.aeruginosa were highly resistant to all investigated antibiotics. Enterobactericeae shown high sensitivity to karbopenemes (95.96%). It is concluded, that success of antimicrobial therapy depends on correct choice of antibiotic, based on in time exposal of etiology of infection, determination of its sensitivity to antimicrobial remedy, considering of its pharmacocinetical features.

摘要

本文的目的是确定糖尿病足感染中感染病原体的结构及其对抗生素的敏感性。2005年至2009年期间,对115例确诊为糖尿病足感染的患者进行治疗,共获得295株微生物分离株。其中需氧菌占92.88%,厌氧菌占7.12%。在58.49%的病例中发现了微生物组合,即各种需氧菌;需氧菌与厌氧菌的组合占17.92%;21.70%的患者分离出微生物单培养物。糖尿病足感染中最常见的革兰氏阳性菌感染是金黄色葡萄球菌,革兰氏阴性菌是铜绿假单胞菌。耐甲氧西林金黄色葡萄球菌占57.52%。在95.57%的病例中,金黄色葡萄球菌菌株对万古霉素敏感。铜绿假单胞菌菌株对所有研究的抗生素均具有高度耐药性。肠杆菌科对碳青霉烯类药物表现出高度敏感性(95.96%)。得出的结论是,抗菌治疗的成功取决于基于及时揭示感染病因、确定其对抗菌药物的敏感性并考虑其药代动力学特征而正确选择抗生素。

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