Gopal R A, Acharya S V, Bandgar T, Menon P S, Dalvi A N, Shah N S
Department of Endocrinology, KEM Hospital, Parel, Mumbai, India.
J Postgrad Med. 2010 Apr-Jun;56(2):79-84. doi: 10.4103/0022-3859.65279.
Primary hyperparathyroidism (PHPT) has a variable clinical presentation and symptomatic PHPT is still the predominant form of the disease in India. Data from western India is lacking.
To present the clinical profile of PHPT from western India.
This retrospective study was conducted at a tertiary care referral center.
We analyzed the clinical presentation, biochemical, radiological features, and operative findings in adult patients with PHPT (1986-2008) and compared with our published data of children and adolescent patients with PHPT.
was done with SPSS 16 software.
Seventy-nine patients (F: M-2:1) with age ranging from 21 to 55 years (mean 33.5+/-8.82) were analyzed. Skeletal manifestations (75.5%), renal calculi (40.5%) and proximal muscle weakness (45.5%) were the most common symptoms of presentation with mean duration of symptoms being 33.70 (median: 24, range 1-120) months. Biochemical features included hypercalcemia (total corrected calcium 12.55+/-1.77 mg/dl), low inorganic phosphorus (1.81+/-0.682 mg/dl), elevated total alkaline phosphatase (mean: 762.2; median: 559; range: 50-4930IU/L) and high parathyroid hormone (PTH) (mean+/-SD: 866.61+/-799.15; median: 639.5; range: 52-3820 pg/ml). Preoperative localization was achieved in 74 patients and single adenoma was found during surgery in 72 patients. Hungry bone disease was seen in 30.3% and transient hypoparathyroidism developed in 62% patients. In comparison to PHPT in children there were no significant differences with regard to clinical, laboratory and radiological features.
PHPT in western India is symptomatic disorder with skeletal and renal manifestations at a much younger age. Clinical profile of PHPT in children is similar to that of adults.
原发性甲状旁腺功能亢进症（PHPT）临床表现多样，在印度，有症状的PHPT仍是该病的主要形式。印度西部的数据尚缺。
介绍印度西部PHPT的临床特征。
本回顾性研究在一家三级医疗转诊中心开展。
我们分析了成年PHPT患者（1986 - 2008年）的临床表现、生化、放射学特征及手术结果，并与我们之前发表的儿童和青少年PHPT患者数据进行比较。
使用SPSS 16软件进行。
分析了79例患者（女性:男性为2:1），年龄在21至55岁之间（平均33.5±8.82岁）。骨骼表现（75.5%）、肾结石（40.5%）和近端肌无力（45.5%）是最常见的症状表现，症状平均持续时间为33.70个月（中位数：24个月，范围1 - 120个月）。生化特征包括高钙血症（总校正钙12.55±1.77mg/dl）、低无机磷（1.81±0.682mg/dl）、总碱性磷酸酶升高（平均：762.2；中位数：559；范围：50 - 4930IU/L）以及甲状旁腺激素（PTH）升高（平均±标准差：866.61±799.15；中位数：639.5；范围：52 - 3820pg/ml）。74例患者术前实现了定位，72例患者手术中发现为单发腺瘤。30.3%的患者出现饥饿骨病，62%的患者发生短暂性甲状旁腺功能减退。与儿童PHPT相比，在临床、实验室和放射学特征方面无显著差异。
印度西部的PHPT是一种有症状的疾病，在较年轻的年龄就出现骨骼和肾脏表现。儿童PHPT的临床特征与成人相似。
