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Beta cell adaptation in pregnancy: a major difference between humans and rodents?

作者信息

Genevay M, Pontes H, Meda P

机构信息

Division of Pathology, Geneva University Hospital, Geneva, Switzerland.

出版信息

Diabetologia. 2010 Oct;53(10):2089-92. doi: 10.1007/s00125-010-1848-z. Epub 2010 Jul 10.

DOI:10.1007/s00125-010-1848-z
PMID:20623217
Abstract
摘要

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The role of non-placental signals in the adaptation of islets to pregnancy.非胎盘信号在胰岛适应妊娠过程中的作用。
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Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy.人妊娠期间胰腺β细胞分数面积和β细胞更新的适应性变化。
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Reduced insulin sensitivity and increased β/α cell mass is associated with reduced hepatic insulin-degrading enzyme activity in pregnant rats.在怀孕大鼠中，胰岛素敏感性降低和β/α 细胞质量增加与肝胰岛素降解酶活性降低有关。
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Co-ordinated regulation of neurogenin-3 expression in the maternal and fetal pancreas during pregnancy.孕期母胎胰腺中神经生成素-3表达的协调调控。
Acta Obstet Gynecol Scand. 2014 Nov;93(11):1190-7. doi: 10.1111/aogs.12495. Epub 2014 Sep 23.

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本文引用的文献

1
Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy.人妊娠期间胰腺β细胞分数面积和β细胞更新的适应性变化。
Diabetologia. 2010 Oct;53(10):2167-76. doi: 10.1007/s00125-010-1809-6. Epub 2010 Jun 5.
2
Beta cell coupling and connexin expression change during the functional maturation of rat pancreatic islets.大鼠胰岛功能成熟过程中β细胞偶联和连接蛋白表达的变化。
Diabetologia. 2010 Jul;53(7):1428-37. doi: 10.1007/s00125-010-1726-8. Epub 2010 Apr 2.
3
Expansion of beta-cell mass in response to pregnancy.
妊娠期糖尿病及其亚型的小鼠模型：最新进展和陷阱。
Int J Mol Sci. 2023 Mar 22;24(6):5982. doi: 10.3390/ijms24065982.
4
Gestational diabetes mellitus and its associated factors in Ethiopia: a systematic review and meta-analysis.妊娠期糖尿病及其相关因素在埃塞俄比亚：系统评价和荟萃分析。
Eur J Med Res. 2023 Mar 15;28(1):125. doi: 10.1186/s40001-023-01088-5.
5
Evaluation of the Effects of Harmine on β-cell Function and Proliferation in Standardized Human Islets Using 3D High-Content Confocal Imaging and Automated Analysis.利用 3D 高内涵共聚焦成像和自动化分析评估哈林碱对标准化人胰岛β细胞功能和增殖的影响。
Front Endocrinol (Lausanne). 2022 Jul 4;13:854094. doi: 10.3389/fendo.2022.854094. eCollection 2022.
6
Mechanisms controlling pancreatic islet cell function in insulin secretion.控制胰岛素分泌的胰岛细胞功能的机制。
Nat Rev Mol Cell Biol. 2021 Feb;22(2):142-158. doi: 10.1038/s41580-020-00317-7. Epub 2021 Jan 4.
7
Gestational Diabetes Mellitus: A Harbinger of the Vicious Cycle of Diabetes.妊娠期糖尿病：糖尿病恶性循环的先兆。
Int J Mol Sci. 2020 Jul 15;21(14):5003. doi: 10.3390/ijms21145003.
8
How, When, and Where Do Human β-Cells Regenerate?人类β细胞何时以及如何再生？
Curr Diab Rep. 2019 Jun 27;19(8):48. doi: 10.1007/s11892-019-1176-8.
9
The impact of diagnostic criteria for gestational diabetes on its prevalence: a systematic review and meta-analysis.妊娠期糖尿病诊断标准对其患病率的影响：一项系统评价和荟萃分析。
Diabetol Metab Syndr. 2019 Feb 1;11:11. doi: 10.1186/s13098-019-0406-1. eCollection 2019.
10
Increases in bioactive lipids accompany early metabolic changes associated with β-cell expansion in response to short-term high-fat diet.生物活性脂质的增加伴随着与β细胞扩张相关的早期代谢变化，这是对短期高脂肪饮食的反应。
Am J Physiol Endocrinol Metab. 2018 Dec 1;315(6):E1251-E1263. doi: 10.1152/ajpendo.00001.2018. Epub 2018 Aug 14.
妊娠时β细胞质量的扩增。
Trends Endocrinol Metab. 2010 Mar;21(3):151-8. doi: 10.1016/j.tem.2009.11.001. Epub 2009 Dec 16.
4
The transcriptional response of the islet to pregnancy in mice.小鼠胰岛对妊娠的转录反应。
Mol Endocrinol. 2009 Oct;23(10):1702-12. doi: 10.1210/me.2009-0144. Epub 2009 Jul 2.
5
Pregnancy-induced rise in serum C-peptide concentrations in women with type 1 diabetes.1型糖尿病女性孕期血清C肽浓度升高。
Diabetes Care. 2009 Jun;32(6):1052-7. doi: 10.2337/dc08-1832. Epub 2009 Feb 24.
6
Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice.β细胞增殖的年龄依赖性下降限制了小鼠β细胞再生的能力。
Diabetes. 2009 Jun;58(6):1312-20. doi: 10.2337/db08-1651. Epub 2009 Feb 19.
7
Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo.对人类胰腺β细胞G1/S蛋白质组的研究揭示了细胞周期蛋白依赖性激酶6（cdk-6）和细胞周期蛋白D1在增强人类β细胞在体内的复制和功能方面的潜在治疗作用。
Diabetes. 2009 Apr;58(4):882-93. doi: 10.2337/db08-0631. Epub 2009 Jan 9.
8
Cx36 makes channels coupling human pancreatic beta-cells, and correlates with insulin expression.Cx36形成连接人类胰腺β细胞的通道，并与胰岛素表达相关。
Hum Mol Genet. 2009 Feb 1;18(3):428-39. doi: 10.1093/hmg/ddn370. Epub 2008 Nov 10.
9
Reduced adaptation of the pancreatic B cells during pregnancy is the major causal factor for gestational diabetes: current knowledge and metabolic effects on the offspring.孕期胰腺β细胞适应性降低是妊娠期糖尿病的主要致病因素：当前认知及对后代的代谢影响
Acta Obstet Gynecol Scand. 2008;87(12):1266-70. doi: 10.1080/00016340802443863.
10
Postnatal expansion of the pancreatic beta-cell mass is dependent on survivin.胰腺β细胞团在出生后的扩张依赖于生存素。
Diabetes. 2008 Oct;57(10):2718-27. doi: 10.2337/db08-0170. Epub 2008 Jul 3.