NMR 研究 D-甘露糖全合成（+）-生物素中的手性中间体。
NMR studies on chiral intermediates in the total synthesis of (+)-biotin from D-mannose.
出版信息
Magn Reson Chem. 2010 Aug;48(8):651-5. doi: 10.1002/mrc.2619.
DOI:10.1002/mrc.2619
PMID:20623722
Abstract
The chemical structure and stereochemistry of 12 intermediates in the total synthesis of (+)-biotin starting from D-mannose as chiral pool were completely assigned using one- and two-dimensional NMR experiments, including 1D selective NOE, DEPT, COSY, HSQC and HMBC.
摘要
从 D-甘露糖作为手性源出发，通过 1D 和 2D NMR 实验，包括 1D 选择性 NOE、DEPT、COSY、HSQC 和 HMBC，完全确定了（+）生物素全合成中 12 个中间体的化学结构和立体化学。
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