[Histological and immunohistochemical characteristics of stimulated angiogenesis in transplantation of multipotent stem cells derived from the adipose tissue in patients with chronic ischemia of the extremities].

The cellular technologies application with the objective for the processes of angiogenesis stimulation, in the ischemia conditions, constitutes an actual task for modern stage of a science development, the discovery of a new sources of cells-stimulants for neoangiogenesis is in a progress. The investigation was performed with an objective of studying of histological and immunohistochemical changes in muscular tissue, occurring after autotransplantation of multipotent stromal cells from adipose tissue of the patients, suffering the extremity ischemia. Histological and immunohistochemical investigations (detection of antibodies expression towards Villebrand factor, collagen type IV and vimentin) of processes, occurring in muscular tissue after introduction of multipotent stromal cells from adipose tissue of this patient, were conducted. The reduction of myofibrils ischemic affection and rapid activation of the muscle regenerative potential were shown. There was established a vivid stimulation of the angiogenesis processes during already first month after cellular transplantation performance.