Division of Nephrology, Department of Medicine, University of California, San Francisco, California 94143, USA.
J Biol Chem. 2010 Oct 1;285(40):30363-9. doi: 10.1074/jbc.R110.155341. Epub 2010 Jul 12.
The kidney has a central role in the regulation of blood pressure, in large part through its role in the regulated reabsorption of filtered Na(+). Epithelial Na(+) channels (ENaCs) are expressed in the most distal segments of the nephron and are a target of volume regulatory hormones. A variety of factors regulate ENaC activity, including several aldosterone-induced proteins that are present within an ENaC regulatory complex. Proteases also regulate ENaC by cleaving the channel and releasing intrinsic inhibitory tracts. Polymorphisms or mutations within channel subunits or regulatory pathways that enhance channel activity may contribute to an increase in blood pressure in individuals with essential hypertension.
肾脏在调节血压方面起着核心作用，这在很大程度上是通过其在过滤的 Na(+)的调节重吸收中的作用来实现的。上皮钠通道 (ENaC) 在肾单位的最远端部分表达，是容量调节激素的靶标。多种因素调节 ENaC 的活性，包括存在于 ENaC 调节复合物中的几种醛固酮诱导蛋白。蛋白酶也通过切割通道和释放内在抑制片段来调节 ENaC。通道亚基或调节途径中的突变或多态性，如果增强了通道的活性，可能会导致原发性高血压患者的血压升高。
