Gordon Scott, Durairaj Anita, Lu Jason L, Davidson W Sean
Center for Lipid and Arteriosclerosis Science, University of Cincinnati, 2120 East Galbraith Road, Cincinnati, OH 45237-0507, USA
Curr Cardiovasc Risk Rep. 2010;4(1):1-8. doi: 10.1007/s12170-009-0069-9.
Recent proteomics studies on human plasma high-density lipoprotein (HDL) have discovered up to 50 individual protein constituents. Many of these have known functions that vary surprisingly from the lipid transport roles commonly thought to mediate HDL's ability to protect from coronary artery disease. Given newly discovered roles in inflammation, protease inhibition, complement regulation, and innate immunity, many have begun to view HDL as a broad collection of distinct particle subfamilies, each distinguished by unique protein compositions and functions. Herein we review recent applications of high-resolution proteomics to HDL and summarize evidence supporting the idea of HDL functional subspeciation. These studies have set the stage for a more complete understanding of the molecular basis of HDL functional heterogeneity and hold promise for the identification of new biomarkers that can predict disease or evaluate the success of clinical interventions.
近期针对人类血浆高密度脂蛋白（HDL）的蛋白质组学研究发现了多达50种不同的蛋白质成分。其中许多成分具有已知功能，其功能与通常认为介导HDL预防冠状动脉疾病能力的脂质转运作用惊人地不同。鉴于在炎症、蛋白酶抑制、补体调节和先天免疫方面的新发现作用，许多人开始将HDL视为由不同颗粒亚家族组成的广泛集合，每个亚家族都以独特的蛋白质组成和功能为特征。在此，我们回顾了高分辨率蛋白质组学在HDL研究中的近期应用，并总结了支持HDL功能亚分类观点的证据。这些研究为更全面地理解HDL功能异质性的分子基础奠定了基础，并有望识别可预测疾病或评估临床干预成功与否的新生物标志物。
