Department of Radiology, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Japan.
Ann Nucl Med. 2010 Aug;24(7):559-63. doi: 10.1007/s12149-010-0396-4. Epub 2010 Jul 13.
The purpose of this study was to investigate optimum emission time of deep inspiration breath-hold (DIBH) positron emission tomography-computed tomography (PET-CT).
We collected 15 PET-CT data sets by adding data of every 10 s and acquisition time ranging from 10 s (1 x 10 s acquisition) to 150 s (15 x 10 s acquisition) for both of DIBH mode and free-breathing condition (continuous mode) in phantom study. The coefficient of variation (CV) of radioactivity concentration was compared to determine optimum emission time of PET-CT. We also compared images of DIBH mode and continuous mode to clarify the influence of diaphragmatic movement in clinical setting.
The mean +/- SD of CV in DIBH mode was 1236.3 +/- 323.1. When compared with the CV at 120 s, the relative error of CV is within 10% at 110 s (0.204), 15% at 100 s (0.212), and 20% at 90 s (0.222), respectively. Optimum emission time greater than 90 s is required to obtain clinically available images in DIBH mode. In the clinical setting, the SUV of the lung base and measurements of uptake show little influence by respiration on DIBH PET-CT.
Optimum emission time of DIBH technique greater than 90 s acquisition is preferable for clinical use.
本研究旨在探讨深吸气屏气（DIBH）正电子发射断层扫描-计算机断层扫描（PET-CT）的最佳发射时间。
我们通过在体模研究中添加 10 秒的数据，采集时间从 10 秒（1x10 秒采集）到 150 秒（15x10 秒采集），分别收集了 15 组 DIBH 模式和自由呼吸条件（连续模式）的 PET-CT 数据。比较放射性浓度的变异系数（CV）以确定 PET-CT 的最佳发射时间。我们还比较了 DIBH 模式和连续模式的图像，以阐明在临床环境中膈肌运动的影响。
DIBH 模式下的平均+/-SD 的 CV 为 1236.3+/-323.1。与 120 秒的 CV 相比，110 秒（0.204）、100 秒（0.212）和 90 秒（0.222）时 CV 的相对误差均在 10%以内。需要大于 90 秒的最佳发射时间才能在 DIBH 模式下获得临床可用的图像。在临床环境中，DIBH PET-CT 对肺基底的 SUV 和摄取测量的呼吸影响很小。
大于 90 秒采集的 DIBH 技术的最佳发射时间更适合临床应用。
