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[大脑前动脉迂曲扩张一例报告]

[A case report of dolichoectasia of the anterior cerebral artery].

作者信息

Kawahara Ichiro, Nakamoto Morito, Matsuo Yoshitaka, Tokunaga Yoshiharu

机构信息

Department of Neurosurgery, Nagasaki Prefecture Shimabara Hospital, Japan.

出版信息

No Shinkei Geka. 2010 Jul;38(7):645-50.

PMID:20628191
Abstract

Dolichoectasia of the intracranial arteries is a rare condition, and the vertebrobasilar system and the internal carotid artery is most commonly involved. We describe a rare case of a 60-year-old man with dolichoectasia of the anterior cerebral artery (ACA). The patient presented with continuous vertigo and nausea. CT and MR imaging showed a prominent serpentine structure with calcification and flow void in the region of the interhemispheric fissure, findings which were suspicious for arteriovenous malformation (AVM) or fistula (AVF). A cerebral angiogram demonstrated an extensive dilatation of the ACA above the level of the anterior communicating artery. There was no evidence of AVM or AVF. Although SPECT study revealed a decrease of cerebral blood flow (CBF) in the right frontal lobe, cerebrovascular reserve, as demonstrated by acetazolamide challenge was sufficient for maintenance. Decrease of CBF may have resulted from diaschisis or selective neural cell elimination by old cerebral infarction. The patient was treated with an anti-platelet agent conservatively and the symptoms gradually improved. Cerebral angiography may be needed for definitive diagnosis because cerebral dolichoectasia may mimic CT and MR imaging findings of AVF or AVM. Cerebral hemodynamics must be examined strictly in addition to demonstrating vascular disease by angiography, and SPECT study may play a role in the detection of hemodynamic change induced by dolichoectasia.

摘要

颅内动脉迂曲扩张是一种罕见病症,最常累及椎基底系统和颈内动脉。我们描述了一例罕见的60岁男性大脑前动脉(ACA)迂曲扩张病例。该患者表现为持续性眩晕和恶心。CT和磁共振成像显示在大脑半球间裂区域有一个突出的蜿蜒结构,伴有钙化和血流空洞,这些表现怀疑为动静脉畸形(AVM)或瘘(AVF)。脑血管造影显示大脑前动脉在前交通动脉水平以上广泛扩张。没有AVM或AVF的证据。尽管单光子发射计算机断层扫描(SPECT)研究显示右侧额叶脑血流量(CBF)减少,但乙酰唑胺激发试验显示脑血管储备足以维持。CBF减少可能是由于远隔性脑损伤或陈旧性脑梗死导致的选择性神经细胞清除。该患者接受了抗血小板药物保守治疗,症状逐渐改善。由于脑动脉迂曲扩张可能模仿AVF或AVM的CT和磁共振成像表现,因此可能需要脑血管造影来明确诊断。除了通过血管造影显示血管疾病外,还必须严格检查脑血流动力学,SPECT研究可能在检测由动脉迂曲扩张引起的血流动力学变化中发挥作用。

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