核心启动子识别因子在细胞类型特异性转录和基因调控中的意外作用。
Unexpected roles for core promoter recognition factors in cell-type-specific transcription and gene regulation.
机构信息
Department of Chemistry and Biochemistry, University of Colorado at Boulder, Colorado 80309, USA.
出版信息
Nat Rev Genet. 2010 Aug;11(8):549-58. doi: 10.1038/nrg2847. Epub 2010 Jul 13.
Abstract
The eukaryotic core promoter recognition complex was generally thought to play an essential but passive role in the regulation of gene expression. However, recent evidence now indicates that core promoter recognition complexes together with 'non-prototypical' subunits may have a vital regulatory function in driving cell-specific programmes of transcription during development. Furthermore, new roles for components of these complexes have been identified beyond development; for example, in mediating interactions with chromatin and in maintaining active gene expression across cell divisions.
摘要
真核生物核心启动子识别复合物通常被认为在基因表达调控中发挥着重要但被动的作用。然而，现在有证据表明，核心启动子识别复合物与“非典型”亚基一起，在发育过程中驱动细胞特异性转录程序中可能具有重要的调节功能。此外，这些复合物的组成部分在发育之外也有了新的作用；例如，在介导与染色质的相互作用以及在跨细胞分裂维持活跃的基因表达方面。
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