Tadros Rami, Shakib Sepehr
Department of Clinical Pharmacology, The Royal Adelaide Hospital, South Australia.
Aust Fam Physician. 2010 Jul;39(7):476-9.
Warfarin is a commonly used medication for the prevention and treatment of venous thromboembolism. It can be challenging for both the patient and the prescriber to manage at times.
To describe the mechanism of action of warfarin, and to discuss the indications for warfarinisation, the risks associated with warfarin use, and some of its drug interactions.
The common indications for warfarinisation are atrial fibrillation, venous thromboembolism and prosthetic heart valves. Contraindications include absolute and relative contraindications, and an individualised risk-benefit analyses is required for each patient. There are many interactions with warfarin, including pharmacokinetic and pharmacodynamic. Pharmacokinetic interactions can be monitored by using International Normalised Ratio levels. Pharmacodynamic interactions require knowledge by the prescriber to predict any interactions with warfarin, and International Normalised Ratio monitoring assists.
华法林是预防和治疗静脉血栓栓塞的常用药物。有时，患者和开处方者管理起来都颇具挑战性。
描述华法林的作用机制，并讨论华法林治疗的适应证、使用华法林的风险及其一些药物相互作用。
华法林治疗的常见适应证为心房颤动、静脉血栓栓塞和人工心脏瓣膜。禁忌证包括绝对禁忌证和相对禁忌证，每位患者都需要进行个体化的风险效益分析。华法林存在许多相互作用，包括药代动力学和药效学方面的相互作用。药代动力学相互作用可通过国际标准化比值水平进行监测。药效学相互作用需要开处方者了解相关知识以预测与华法林的任何相互作用，国际标准化比值监测对此有辅助作用。
