膀胱内注射奥昔布宁可保护逼尿肌过度活动兔的膀胱壁，防止其功能和平滑肌发生改变。
Intravesical oxybutynin protects the vesical wall against functional and smooth muscle changes in rabbits with detrusor overactivity.
作者信息
Polido Júnior Armando, Costa José Mateus, Munhoz Tânia, Sampaio Francisco José, Cardoso Luiz Eduardo Macedo, Amaro João Luiz
机构信息
Department of Urology, School of Medicine, UNESP, Botucatu, Brazil.
出版信息
Int Urogynecol J. 2010 Dec;21(12):1539-44. doi: 10.1007/s00192-010-1219-9. Epub 2010 Jul 14.
INTRODUCTION AND HYPOTHESIS
The aim of this study was to evaluate the protective effect of intravesical oxybutynin on the bladder wall of rabbits with detrusor overactivity and partial bladder outlet obstruction (PBOO).
METHODS
Forty-five North Folk male rabbits were randomly distributed into GI, used as control (n = 15), GII-PBOO (n = 14), and GIII-PBOO + intravesical oxybutynin (n = 15). Connective tissue and elastic fibers were quantified as volumetric density on picrosirius red and Weigert's Fuchsin-Resorcin-stained sections, respectively.
RESULTS
In T2, bladder weight was significantly higher in animals in GII and GIII. Smooth muscle bundle diameter was increased by 42% in GII compared with GI (p < 0.02).Elastic fibers were significantly higher in GII and GIII as compared with control group. Collagen concentration in GIII and GII was significantly lower than G1 (p < 0.025).
CONCLUSION
Intravesical oxybutynin protected against structural and functional detrusor modifications of the partially obstructed bladder.
引言与假设
本研究旨在评估膀胱内使用奥昔布宁对逼尿肌过度活动和部分膀胱出口梗阻（PBOO）家兔膀胱壁的保护作用。
方法
45只北方雄性家兔随机分为三组，GI组作为对照组（n = 15），GII - PBOO组（n = 14），GIII - PBOO +膀胱内奥昔布宁组（n = 15）。分别在天狼星红染色切片和魏格特氏品红 - 间苯二酚染色切片上，将结缔组织和弹性纤维定量为体积密度。
结果
在T2期，GII组和GIII组动物的膀胱重量显著更高。与GI组相比，GII组平滑肌束直径增加了42%（p < 0.02）。与对照组相比，GII组和GIII组的弹性纤维显著更高。GIII组和GII组的胶原蛋白浓度显著低于G1组（p < 0.025）。
结论
膀胱内使用奥昔布宁可预防部分梗阻膀胱逼尿肌的结构和功能改变。
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