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[CPC/氨磷汀/顺铂复合物的体外药物递送及其体内修复骨缺损和消除肿瘤的能力]

[Drug delivery of CPC/amifostine/cisplatin complex in vitro and its ability in repairing bone defect and eliminating tumor in vivo].

作者信息

Liu Yan-Ning, Liu Miao, Ren Peng-Yu

机构信息

Department of Orthopaedics, the First Affiliated Hospital, Medical Shool of Xi'an Jiaotong University, Xi'an 710061, China.

出版信息

Sichuan Da Xue Xue Bao Yi Xue Ban. 2010 May;41(3):471-5.

PMID:20629324
Abstract

OBJECTIVE

To investigate the feasibility of using calcium phosphate cement/amifostine/cisplatin complex to fill and repair bone defect, caused by tumor resection.

METHODS

Drug concentration in the CPC/ amifostine/cisplatin complex was determined. Rabbits with bone defect and rats with osteosarcoma were implanted with CPC and CPC/amifostine/cisplatin complex.

RESULTS

Similar bone growth was observed in the femurs of rabbits implanted with CPC/amifostine/cisplatin complex and those implanted with CPC. CPC/amifostine/cisplatin complex delivered amifostine and cisplatin consistently and eliminated osteosarcoma cells implanted in the rats.

CONCLUSION

CPC/amifostine/cisplatin complex repairs bone defect caused by tumors as a filling material.

摘要

目的

探讨磷酸钙骨水泥/氨磷汀/顺铂复合物填充修复肿瘤切除所致骨缺损的可行性。

方法

测定磷酸钙骨水泥/氨磷汀/顺铂复合物中的药物浓度。将骨缺损兔和骨肉瘤大鼠分别植入磷酸钙骨水泥和磷酸钙骨水泥/氨磷汀/顺铂复合物。

结果

植入磷酸钙骨水泥/氨磷汀/顺铂复合物的兔股骨与植入磷酸钙骨水泥的兔股骨有相似的骨生长情况。磷酸钙骨水泥/氨磷汀/顺铂复合物持续释放氨磷汀和顺铂，并消除了植入大鼠体内的骨肉瘤细胞。

结论

磷酸钙骨水泥/氨磷汀/顺铂复合物作为填充材料可修复肿瘤所致骨缺损。

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Sichuan Da Xue Xue Bao Yi Xue Ban. 2010 May;41(3):471-5.
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