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序列变异性和序列进化:解释分子多态性,以及为什么许多分子结构尽管不占优势,却能被保存下来。

Sequence variability and sequence evolution: an explanation of molecular polymorphisms and why many molecular structures can be preserved although they are not predominant.

机构信息

Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University, Mainz, Germany.

出版信息

DNA Cell Biol. 2010 Oct;29(10):571-6. doi: 10.1089/dna.2009.0942.

Abstract

The existence of many processes that regulate RNA expression poses a challenge to the idea that the cell is the culmination of a highly efficient interplay of individual proteins, each with specific, highly specialized functions. It will be demonstrated here the extent to which the cell may undergo evolutionary processes that also occur in the macrocosmos, specifically with reference to the rules of mutation and preservation. These molecular evolutionary processes could facilitate a better understanding of the development of molecular structures and the functioning of the cell and could give an explanation of the molecular polymorphisms and also explain why many molecular structures can be preserved although they are not predominant.

摘要

许多调控 RNA 表达的过程的存在,对细胞是个体蛋白高度有效相互作用的产物这一观点提出了挑战,而这些蛋白各自具有特定的、高度专业化的功能。这里将展示细胞在多大程度上经历了同样也发生在宏观世界中的进化过程,特别是参考突变和保存的规则。这些分子进化过程有助于更好地理解分子结构的发育和细胞的功能,并能解释分子多态性,也能解释为什么许多分子结构虽然不占优势但仍能被保存。

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