Pérez Roldán Francisco, Vives Domínguez Leopoldo, González Carro Pedro, Villafáñez García Maria Concepción, Fernández Acenero Maria Jesús, Cuesta Domínguez Rubén, Aoufi Rabih Sami, Ruíz Carrillo Francisco
Hospital General La Mancha-Centro, Alcázar de San Juan, España.
Gastroenterol Hepatol. 2010 Aug-Sep;33(7):498-503. doi: 10.1016/j.gastrohep.2010.04.007. Epub 2010 Jul 14.
Reversibility of liver fibrosis or cirrhosis involves complete restoration of normal liver architecture. This phenomenon has been well documented in chronic liver diseases such as autoimmune hepatitis, biliary obstruction, hemochromatosis, nonalcoholic steatohepatitis, and viral hepatitis. There are very few reports of reversal of cirrhosis after antiviral therapy in patients with chronic hepatitis B virus (HBV) infection. We report a case of disappearance of HBV-induced liver cirrhosis after years of treatment with distinct antiviral drugs, documented by successive biopsy results. This disappearance was accompanied by normalization of platelet count, gammaglobulin titers, and radiologic findings.
肝纤维化或肝硬化的逆转涉及正常肝脏结构的完全恢复。这种现象在自身免疫性肝炎、胆管梗阻、血色素沉着症、非酒精性脂肪性肝炎和病毒性肝炎等慢性肝病中已有充分记录。关于慢性乙型肝炎病毒（HBV）感染患者抗病毒治疗后肝硬化逆转的报道非常少。我们报告一例经连续活检结果证实，在使用不同抗病毒药物治疗多年后，HBV 诱导的肝硬化消失的病例。这种消失伴随着血小板计数、γ球蛋白滴度和影像学检查结果的正常化。
