University of Denver, Department of Biological Sciences, Denver, Colorado, USA.
Ann N Y Acad Sci. 2010 Jul;1200:85-94. doi: 10.1111/j.1749-6632.2010.05515.x.
In gnathostomes the kappa, mu, delta, ORL-1 receptor genes constitute the opioid/ORL-1 receptor gene family. These genes are most likely the result of two (2R) genome duplication events that occurred during the radiation of the chordates. In stilico analysis of the genome of the lamprey, Petromyzon marius, revealed the partial sequences of four genes that may be the result of a lineage specific genome duplication event in the lamprey lineage. The sequencing of cDNAs from the lamprey CNS supports the assumption that these putative lamprey opioid-like receptor genes are expressed by lamprey neurons. Analysis of gnathostome ORL-1 receptor sequences support the hypothesis that the ORL-1 gene has undergone a transition from an opioid receptor that could bind several types of opioid ligands to a receptor in mammals that can only be activated by the FGGF form of the orphanin ligand.
在有颌类动物中，kappa、mu、delta、ORL-1 受体基因构成了阿片类/ORL-1 受体基因家族。这些基因很可能是在脊索动物辐射过程中发生的两次（2R）基因组加倍事件的结果。对七鳃鳗 Petromyzon marius 基因组的计算机分析揭示了四个基因的部分序列，这些基因可能是七鳃鳗谱系中特定谱系基因组加倍事件的结果。从七鳃鳗中枢神经系统 cDNA 的测序支持了这样一种假设，即这些假定的七鳃鳗阿片样受体基因是由七鳃鳗神经元表达的。对颌骨动物 ORL-1 受体序列的分析支持了这样一种假设，即 ORL-1 基因已经从一种能够结合多种类型阿片类配体的阿片受体转变为一种在哺乳动物中只能被孤儿配体 FGGF 形式激活的受体。
