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外周血 T 调节细胞计数可能无法预测移植排斥反应。

Peripheral blood T regulatory cell counts may not predict transplant rejection.

机构信息

Key Laboratory of Transplant Engineering and Immunology, Ministry of Health, West China Hospital, Sichuan University, Chengdu China.

出版信息

BMC Immunol. 2010 Jul 15;11:40. doi: 10.1186/1471-2172-11-40.

DOI:10.1186/1471-2172-11-40
PMID:20633262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2912834/
Abstract

BACKGROUND

Recent evidence shows that allograft survival rates show a positive correlation with the number of circulating T regulatory cells (Tregs). This study investigated both the number and the cytokine profiles exhibited by Foxp3+ Tregs in blood, spleen and lymph nodes of Lewis rat recipients of BN rat cardiac allografts after a single-dose of Rapamycin (RAPA).

RESULTS

Rats were divided into three groups: control group (containing healthy control and acute rejection group), and recipients treated with a single dose of RAPA on either Day 1 (1D group)or Day 3 (3D group) post-transplant. We analyzed the number of Foxp3+Tregs and the expression of Foxp3 and cytokines in the peripheral blood and the peripheral lymphoid tissues. No difference was found in the numbers of circulating Foxp3+ Tregs between these three groups. RAPA administration significantly increased Foxp3 expression in peripheral lymphoid tissues after a single dose of RAPA on Day 3 post-transplant. Foxp3+Tregs inhibited the activity of effector T cells (Teff) via the secretion of TGF-beta1.

CONCLUSION

The number of Tregs in the recipient's blood may not be a good predictor of transplant rejection. Foxp3+Tregs inhibit the activity of Teff cells mainly in the peripheral lymphoid tissues.

摘要

背景

最近的证据表明，同种异体移植物的存活率与循环 T 调节细胞（Tregs）的数量呈正相关。本研究在单次给予雷帕霉素（RAPA）后，观察了 BN 大鼠心脏移植物接受者的血液、脾脏和淋巴结中 Foxp3+Tregs 的数量及其细胞因子谱。

结果

大鼠分为三组：对照组（包含健康对照组和急性排斥组）和移植后第 1 天（1D 组）或第 3 天（3D 组）单次接受 RAPA 治疗的接受者组。我们分析了外周血和外周淋巴组织中 Foxp3+Tregs 的数量以及 Foxp3 和细胞因子的表达。这三组之间循环 Foxp3+Tregs 的数量没有差异。在移植后第 3 天单次给予 RAPA 后，外周淋巴组织中 Foxp3 表达显著增加。Foxp3+Tregs 通过分泌 TGF-β1 抑制效应 T 细胞（Teff）的活性。

结论

受者血液中的 Tregs 数量可能不是移植排斥的良好预测指标。Foxp3+Tregs 主要在外周淋巴组织中抑制 Teff 细胞的活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de33/2912834/2144c9f06bcc/1471-2172-11-40-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de33/2912834/75c99751cb29/1471-2172-11-40-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de33/2912834/df464c2de5f7/1471-2172-11-40-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de33/2912834/7d8e8e00b95b/1471-2172-11-40-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de33/2912834/54c03b211400/1471-2172-11-40-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de33/2912834/d7187c2e2901/1471-2172-11-40-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de33/2912834/2144c9f06bcc/1471-2172-11-40-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de33/2912834/75c99751cb29/1471-2172-11-40-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de33/2912834/df464c2de5f7/1471-2172-11-40-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de33/2912834/7d8e8e00b95b/1471-2172-11-40-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de33/2912834/54c03b211400/1471-2172-11-40-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de33/2912834/d7187c2e2901/1471-2172-11-40-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de33/2912834/2144c9f06bcc/1471-2172-11-40-6.jpg

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A modified technique for heterotopic heart transplantation in rats.大鼠异位心脏移植的改良技术。
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