Kolodkina L A, Shkliarevich N A, Dovnar T E
Ter Arkh. 1991;63(3):27-30.
The authors describe changes in functional activity of peripheral blood leukocytes, namely in the absorptive capacity, metabolic activation, chemotaxis in vivo and in vitro in patients with grave acute pneumonia (n-102) and destructive pneumonia (n-16). At the stage of active inflammation, the patients with acute pneumonia showed a decrease in leukocyte function (chemotaxis and phagocytosis) and metabolic activation of that cell type, related to the growth of the output of the toxic forms of oxygen. The changes revealed were found to be dependent on the activity of inflammation and volume of infiltration in the pulmonary tissue. The functional changes in leukocytes discovered in patients suffering from acute pneumonia, particularly in those with destruction confirm the possibility that those cells are involved into the pathogenesis of the destructive process.
作者描述了重症急性肺炎患者（n = 102）和坏死性肺炎患者（n = 16）外周血白细胞功能活性的变化，即体内和体外的吸收能力、代谢激活、趋化性。在急性炎症阶段，急性肺炎患者白细胞功能（趋化性和吞噬作用）下降，且该细胞类型的代谢激活与毒性氧形式输出的增加有关。发现所揭示的这些变化取决于炎症活动和肺组织浸润范围。在急性肺炎患者中发现的白细胞功能变化，尤其是坏死性肺炎患者，证实了这些细胞参与坏死性病变发病机制的可能性。
