Logvinov S V, Plotnikov M B, Zhdankina A A, Smolyakova V I, Ivanov I S, Kuchin A V, Chukicheva I V, Varakuta E Yu
Department of Histology, Embryology, and Cytology, Siberian State Medical University, Tomsk, Russia.
Neurosci Behav Physiol. 2010 Sep;40(7):779-82. doi: 10.1007/s11055-010-9326-0. Epub 2010 Jul 17.
Along with microangiopathy, one of the main causes of blindness in diabetic retinopathy consists of degeneration of retinal neurons. Electron microscopy and morphometric analysis were used to study structural changes in neurosensory cells, associative, and ganglion neurons in the retina in 30 while mongrel male rats with streptozotocin diabetes for two months and the effects of a new semisynthetic antioxidant 4-methyl-2,6-diisobornylphenol, a screened phenol, were evaluated. Destructive changes were found to affect the outer segments of neurosensory cells and ganglion neurons. The number density of neurosensory and ganglion cells decreased, and the proportion of these cells with pyknotic nuclei increased. 4-Methyl-2,6-diisobornylphenol had neuroprotective actions, preventing destructive changes to neurosensory cells and ganglion neurons.
除微血管病变外，糖尿病视网膜病变致盲的主要原因之一是视网膜神经元变性。采用电子显微镜和形态计量分析方法，对30只链脲佐菌素诱导糖尿病2个月的杂种雄性大鼠视网膜中的神经感觉细胞、联合神经元和神经节神经元的结构变化进行了研究，并评估了一种新的半合成抗氧化剂4-甲基-2,6-二异冰片基苯酚（一种筛选出的苯酚）的作用。发现破坏性变化影响神经感觉细胞和神经节神经元的外段。神经感觉细胞和神经节细胞的数量密度降低，这些细胞核固缩的细胞比例增加。4-甲基-2,6-二异冰片基苯酚具有神经保护作用，可防止神经感觉细胞和神经节神经元发生破坏性变化。
