Chen Si-Xiu, Li Xiao-Yu, Kong Xiang-Li, Feng Yun
State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2010 Jun;28(3):319-23.
To study the expression of vascular endothelial growth factor-C (VEGF-C) in oral squamous cell carcinoma (OSCC) and its relation to angiogenesis, lymphangiogenesis, as well as lymph node metastasis.
Sixty-seven archival specimens from patients with oral squamous cell carcinoma were investigated, whose clinicopathologic data were completely conserved. Immunohistochemical staining was performed to detect the expression of VEGF-C, microvessel density (MVD), lymphatic vessel density (LVD). The correlations between VEGF-C expression and MVD, LVD, as well as other clinicopathological features were measured.
Although no correlation between VEGF-C expression and tumor location, histological grade, or gender of the patients was observed (P > 0.05), OSCC patients with more advanced clinical stages and lymph node metastasis were prone to have high expression of VEGF-C (P = 0.015 and P < 0.001, respectively). Cases with high-expression of VEGF-C also showed significantly more often higher LVD (P = 0.001) but not MVD (P = 0.125). In addition, cases with lymph node involvement presented higher LVD than other cases (P = 0.026).
VEGF-C may promote lymph node metastasis by inducing lymphangiogenesis in OSCC.
研究血管内皮生长因子-C（VEGF-C）在口腔鳞状细胞癌（OSCC）中的表达及其与血管生成、淋巴管生成以及淋巴结转移的关系。
对67例口腔鳞状细胞癌患者的存档标本进行研究，其临床病理数据保存完整。采用免疫组织化学染色检测VEGF-C、微血管密度（MVD）、淋巴管密度（LVD）的表达。测定VEGF-C表达与MVD、LVD以及其他临床病理特征之间的相关性。
虽然未观察到VEGF-C表达与肿瘤位置、组织学分级或患者性别之间存在相关性（P>0.05），但临床分期较晚和有淋巴结转移的OSCC患者更容易出现VEGF-C高表达（分别为P=0.015和P<0.001）。VEGF-C高表达的病例也更常表现出较高的LVD（P=0.001），但MVD无差异（P=0.125）。此外，有淋巴结受累的病例LVD高于其他病例（P=0.026）。
VEGF-C可能通过诱导OSCC中的淋巴管生成促进淋巴结转移。
