Department of Drug Safety Management, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan.
J Palliat Med. 2010 Jul;13(7):841-6. doi: 10.1089/jpm.2010.0065.
The use of opioid analgesics and nonopioid medicines for the treatment of various symptoms in regional cancer centers is considered to be an index of the effectiveness of the structural plan for palliative care in such institutions. The present study aimed to establish an accurate representation of the actual use of opioid analgesics for palliative care in regional cancer centers.
In November 2007, a questionnaire regarding the use of medications for palliative care was conducted in 288 regional cancer centers in Japan. Valid responses were received from 264 institutions (response rate, 91.4%).
All regional cancer centers reported using both opioid analgesics and nonopioid medicines. However, regarding opioid analgesics, the use of each standard strength ranged from 7% to 100%. The total amount of opioid analgesics used was 1739.6 +/- 1216.5 g (mean +/- SD). Factors found to be significantly related to the total amount of opioid analgesics used in an institution were the number of opioid analgesic medicines in use (p = 0.008), the number of inpatients with cancer (p < 0.001), the number of deaths among patients with cancer (p < 0.001), and the number of beds (p < 0.001).
Increase in the amount of opioid analgesics might improve the quality of palliative care at regional cancer centers.
在区域癌症中心，使用阿片类镇痛药和非阿片类药物治疗各种症状被认为是这些机构姑息治疗结构计划有效性的指标。本研究旨在准确描述区域癌症中心姑息治疗中阿片类镇痛药的实际使用情况。
2007 年 11 月，对日本 288 个区域癌症中心进行了姑息治疗药物使用情况的问卷调查。有效回复来自 264 个机构（应答率为 91.4%）。
所有区域癌症中心均报告同时使用阿片类镇痛药和非阿片类药物。然而，对于阿片类镇痛药，每种标准强度的使用率在 7%至 100%之间。使用的阿片类镇痛药总量为 1739.6 +/- 1216.5g（平均值 +/- SD）。与机构内阿片类镇痛药使用总量显著相关的因素包括：使用的阿片类镇痛药品种数（p=0.008）、癌症住院患者人数（p<0.001）、癌症患者死亡人数（p<0.001）和病床数（p<0.001）。
阿片类镇痛药使用量的增加可能会提高区域癌症中心姑息治疗的质量。
