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2
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本文引用的文献

1
The opportunity for psychiatry in palliative care.姑息治疗中的精神病学机遇。
Can J Psychiatry. 2008 Nov;53(11):713-24. doi: 10.1177/070674370805301103.
2
Intravenous ketamine "burst" for refractory depression in a patient with advanced cancer.静脉注射氯胺酮“冲击疗法”用于一名晚期癌症患者的难治性抑郁症治疗
J Palliat Med. 2008 Nov;11(9):1268-71. doi: 10.1089/jpm.2008.9828.
3
Repeated intravenous ketamine therapy in a patient with treatment-resistant major depression.重复静脉注射氯胺酮治疗治疗抵抗性重度抑郁症患者。
World J Biol Psychiatry. 2009;10(4 Pt 2):640-3. doi: 10.1080/15622970701420481.
4
Intravenous ketamine therapy in a patient with a treatment-resistant major depression.对一名难治性重度抑郁症患者进行静脉注射氯胺酮治疗。
Swiss Med Wkly. 2007 Apr 21;137(15-16):234-6. doi: 10.4414/smw.2007.11852.
5
Ketamine and the potential role for rapid-acting antidepressant medications.氯胺酮及速效抗抑郁药物的潜在作用。
Swiss Med Wkly. 2007 Apr 21;137(15-16):215-6. doi: 10.4414/smw.2007.11932.
6
Cognitive therapy versus medication in augmentation and switch strategies as second-step treatments: a STAR*D report.作为第二步治疗的增效和换药策略中认知疗法与药物治疗的比较：STAR*D报告
Am J Psychiatry. 2007 May;164(5):739-52. doi: 10.1176/ajp.2007.164.5.739.
7
Depression and anxiety disorders in palliative cancer care.姑息性癌症护理中的抑郁症和焦虑症。
J Pain Symptom Manage. 2007 Feb;33(2):118-29. doi: 10.1016/j.jpainsymman.2006.07.016.
8
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.一项关于N-甲基-D-天冬氨酸拮抗剂治疗难治性重度抑郁症的随机试验。
Arch Gen Psychiatry. 2006 Aug;63(8):856-64. doi: 10.1001/archpsyc.63.8.856.
9
Two case studies of patients with major depressive disorder given low-dose (subanesthetic) ketamine infusions.两项关于重度抑郁症患者接受低剂量（亚麻醉剂量）氯胺酮输注的病例研究。
Pain Med. 2006 Jan-Feb;7(1):92-5. doi: 10.1111/j.1526-4637.2006.00101.x.
10
Use of methylphenidate in patients with cancer.哌甲酯在癌症患者中的应用。
Am J Hosp Palliat Care. 2006 Jan-Feb;23(1):35-40. doi: 10.1177/104990910602300106.

口服用氯胺酮快速治疗接受临终关怀患者的抑郁和焦虑。

Oral ketamine for the rapid treatment of depression and anxiety in patients receiving hospice care.

机构信息

Institute for Palliative Medicine at San Diego Hospice, Palliative Care Psychiatry, San Diego, California 92103, USA.

出版信息

J Palliat Med. 2010 Jul;13(7):903-8. doi: 10.1089/jpm.2010.9808.

DOI:10.1089/jpm.2010.9808
PMID:20636166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3120058/
Abstract

Depression is prevalent and undertreated in patients receiving hospice care. Standard antidepressants do not work rapidly or often enough to benefit most of these patients. Here, two cases are reported in which a single oral dose of ketamine provided rapid and moderately sustained symptom relief for both depression and anxiety. In addition, no adverse effects were noted. Further investigation with randomized, controlled clinical trials is necessary to firmly establish the effectiveness of oral ketamine for the treatment of depression and anxiety in patients receiving hospice care. Ketamine may be a promising safe, effective, and cost-effective rapid treatment for depression and anxiety in this population.

摘要

接受临终关怀的患者中普遍存在且未得到充分治疗的抑郁症。标准的抗抑郁药不能迅速或经常起效，无法使大多数患者受益。这里报告了两例病例，单次口服氯胺酮可迅速且适度地缓解抑郁和焦虑症状。此外，未观察到不良反应。需要进行随机对照临床试验的进一步研究，以确定口服氯胺酮治疗接受临终关怀的患者的抑郁和焦虑的有效性。氯胺酮可能是一种有前途的安全、有效且具有成本效益的快速治疗该人群抑郁和焦虑的方法。