van der Naalt J, Fidler V, Oosterhuis H J
Department of Neurology, University Hospital Groningen, The Netherlands.
Acta Neurol Scand. 1991 May;83(5):297-300. doi: 10.1111/j.1600-0404.1991.tb04705.x.
The vibration perception threshold (VPT) was investigated by means of a biothesiometer among 40 patients with insulin dependent diabetes mellitus. The age as well as the duration of the disease affected the VPT. However, a correlation between the VPT and the rate of metabolic control measured through the glycolysed Hb (HbAlc) could not be demonstrated. In early stages abnormalities were already detectable in the feet. The VPT was elevated in 13 of 20 patients with sensory complaints and in 4 of 20 patients without complaints. Routine neurological examinations such as light touch and pinprick sensation were less sensitive to diagnose neuropathy. In detecting early signs of diabetic neuropathy in an outpatient population the determination of the VPT is a sensitive tool.
采用生物感觉阈值测量仪对40例胰岛素依赖型糖尿病患者的振动觉阈值（VPT）进行了研究。年龄和病程均会影响VPT。然而，未发现VPT与通过糖化血红蛋白（HbAlc）测得的代谢控制率之间存在相关性。在疾病早期，足部就已能检测到异常。20例有感觉异常主诉的患者中有13例VPT升高，20例无主诉的患者中有4例VPT升高。诸如轻触觉和针刺觉等常规神经学检查对神经病变的诊断敏感性较低。在门诊人群中检测糖尿病神经病变的早期迹象时，VPT测定是一种敏感的工具。
