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精神兴奋剂使用者的心血管疾病风险因素和症状。

Cardiovascular disease risk factors and symptoms among regular psychostimulant users.

机构信息

National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW 2052, Australia.

出版信息

Drug Alcohol Rev. 2010 Jul;29(4):371-7. doi: 10.1111/j.1465-3362.2009.00158.x.

DOI:10.1111/j.1465-3362.2009.00158.x
PMID:20636652
Abstract

INTRODUCTION AND AIMS

The aim of this study is to determine the prevalence of risk factors and possible symptoms of cardiovascular disease among regular psychostimulant users.

DESIGN AND METHODS

A total of 239 regular psychostimulant users were administered a structured interview on health and cardiovascular disease symptoms.

RESULTS

Thirty per cent had a family history of cardiovascular disease, 37% had sought treatment for possible symptoms of cardiovascular disease and 14% had been prescribed medications for symptoms of possible cardiovascular problems. The most commonly reported severe symptoms were: chronic shortness of breath (17%), chest pains (15%), palpitations (14%), chronic fatigue (13%) and dizziness/loss of consciousness (11%). Chest pains had been experienced on at least a weekly basis in the past 12 months by 13%. All symptoms occurred at significantly higher levels after the initiation of psychostimulant use. Higher levels of psychostimulant dependence were positively correlated with the number of frequently occurring symptoms (r = 0.23). Independent correlates of higher levels of frequently occurring symptoms were higher level of psychostimulant dependence, higher levels of alcohol dependence, a family history of cardiovascular disease and a diagnosis of cardiovascular disease.

DISCUSSION AND CONCLUSIONS

While a great deal of clinical attention has been given to the sequelae of psychostimulant use, such as psychosis, the potential effects upon the cardiovascular systems of users are worthy of specific public health attention.

摘要

简介和目的

本研究旨在确定心血管疾病风险因素和可能症状在经常使用精神兴奋剂的人群中的流行情况。

设计和方法

共对 239 名经常使用精神兴奋剂的患者进行了健康和心血管疾病症状的结构化访谈。

结果

30%的人有心血管疾病家族史,37%的人因可能的心血管疾病症状寻求治疗,14%的人因可能的心血管问题症状开了处方。报告的最常见严重症状为:慢性呼吸急促(17%)、胸痛(15%)、心悸(14%)、慢性疲劳(13%)和头晕/意识丧失(11%)。过去 12 个月中,至少每周有 13 人出现胸痛。所有症状在开始使用精神兴奋剂后出现的频率明显更高。精神兴奋剂依赖程度越高,经常发生的症状数量越多(r = 0.23)。经常发生的症状水平较高的独立相关因素包括:精神兴奋剂依赖程度较高、酒精依赖程度较高、心血管疾病家族史和心血管疾病诊断。

讨论和结论

虽然大量临床注意力都集中在精神兴奋剂使用的后果,如精神病上,但使用者的心血管系统的潜在影响值得特别关注公共卫生。

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