与绿猴婴儿死亡率相关的胎儿和母体因素。
Fetal and maternal factors associated with infant mortality in vervet monkeys.
作者信息
Kavanagh K, Dozier B L, Chavanne T J, Fairbanks L A, Jorgensen M J, Kaplan J R
机构信息
Pathology, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC, USA.
出版信息
J Med Primatol. 2011 Feb;40(1):27-36. doi: 10.1111/j.1600-0684.2010.00441.x.
BACKGROUND
Causes of infant death remain unknown in significant proportions of human and non-human primate pregnancies.
METHODS
A closed breeding colony with high rates of infant mortality had pregnancies assessed (n=153) by fetal measurements and maternal characteristics. Infant outcome was classified as neonatal death (stillborn or died <48 hours from birth), postnatal death (died 2-30 days) or surviving (alive after 30 days).
RESULTS
Fetal size did not predict outcome. Poor maternal glycemic control and low social ranking increased odds for adverse outcome (OR=3.72, P=0.01 and 2.27, P=0.04, respectively). Male sex was over-represented in stillbirths (P=0.04), and many were macrosomic, but size did not associate with maternal glycemic control measured as glycated hemoglobin A1c. Postnatally dead infants were smaller (P<0.01), which associated with behavioral factors and glycemic control.
CONCLUSIONS
Fetal growth estimates predicted gestational age but not fetal outcome. Maternal social status and metabolic health, particularly glycemic control, increased risks of adverse pregnancy outcome.
背景
在相当比例的人类和非人灵长类动物妊娠中，婴儿死亡原因仍然不明。
方法
对一个婴儿死亡率高的封闭繁殖群体中的妊娠情况（n = 153）进行评估，评估指标包括胎儿测量数据和母体特征。婴儿结局分为新生儿死亡（死产或出生后<48小时死亡）、产后死亡（2 - 30天死亡）或存活（30天后存活）。
结果
胎儿大小不能预测结局。母体血糖控制不佳和社会地位低会增加不良结局的几率（分别为OR = 3.72，P = 0.01和2.27，P = 0.04）。死产中男性比例过高（P = 0.04），且许多为巨大儿，但胎儿大小与以糖化血红蛋白A1c衡量的母体血糖控制无关。产后死亡的婴儿较小（P<0.01），这与行为因素和血糖控制有关。
结论
胎儿生长估计可预测孕周，但不能预测胎儿结局。母体社会地位和代谢健康状况，尤其是血糖控制，会增加不良妊娠结局的风险。
Zotero 插件