一种与两例非人灵长类动物死产相关的新型布鲁氏菌分离株——首例报告。
A novel Brucella isolate in association with two cases of stillbirth in non-human primates - first report.
作者信息
Schlabritz-Loutsevitch Natalia E, Whatmore Adrian M, Quance Christine R, Koylass Mark S, Cummins L Bill, Dick Edward J, Snider Cathy L, Cappelli David, Ebersole Jeffrey L, Nathanielsz Peter W, Hubbard Gene B
机构信息
Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
出版信息
J Med Primatol. 2009 Feb;38(1):70-3. doi: 10.1111/j.1600-0684.2008.00314.x.
BACKGROUND
Brucellosis is veterinary and human health problem.
METHODS
A 13-year-old wild caught multiparous and an 8-year-old colony-born nulliparous baboon had stillbirths in the second trimester of pregnancy. Culture isolates from both postpartum uteruses were characterized using traditional biochemical analysis, PCR, and multilocus sequencing.
RESULTS
The isolates morphologically resembled Brucella although their phenotypic characteristics were not consistent with any currently described species. The isolates represent a novel lineage within the genus with unique alleles, not previously seen in surveys of greater than 300 isolates representing the known diversity of the genus, present at 5/9 loci examined.
CONCLUSIONS
The described cases are to the best of our knowledge the first presentation of a naturally acquired Brucella infection in non-human primates associated with stillbirths from the same colony where Brucella seropositivity in the baboons was described 45 years ago. The organism appears to represent a previously undescribed Brucella species.
背景
布鲁氏菌病是兽医和人类健康问题。
方法
一只13岁野生捕获的经产狒狒和一只8岁圈养出生的未产狒狒在妊娠中期出现死产。使用传统生化分析、聚合酶链反应（PCR）和多位点测序对两只产后子宫的培养分离株进行特征分析。
结果
这些分离株在形态上类似于布鲁氏菌，尽管其表型特征与目前描述的任何物种都不一致。这些分离株代表了该属内的一个新谱系，具有独特的等位基因，在检测的9个位点中的5个位点上存在独特等位基因，这在对代表该属已知多样性的300多个分离株的调查中从未见过。
结论
据我们所知，所描述的病例是首次在非人类灵长类动物中出现自然获得性布鲁氏菌感染并伴有死产，该灵长类动物来自45年前曾描述过狒狒布鲁氏菌血清阳性的同一群体。该生物体似乎代表了一种先前未描述过的布鲁氏菌物种。
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