Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland.
Oral Oncol. 2010 Sep;46(9):636-43. doi: 10.1016/j.oraloncology.2010.06.008. Epub 2010 Jul 15.
Squamous cell carcinoma of the oral (mobile) tongue (OTSCC) is increasingly regarded as a biologically different entity compared to cancer affecting other oral sites. It is more aggressive and generally associated with a higher rate of metastasis. This is the concluding part of our two-part article that examines the methods by which the behavior and prognosis of OTSCC has been studied, the prognostics markers, and the relevance and future direction of prognostic studies. In this part, we continue our discussion of the histopathologic and molecular prognostic factors, and serum and salivary biomarkers in of OTSCC, and emphasize the need to regard OTSCC as a high risk variant of oral cancer. We conclude with future direction of prognostic studies of OTSCC.
口腔（活动）舌部鳞状细胞癌（OTSCC）与发生在其他口腔部位的癌症相比，越来越被认为是一种生物学上不同的实体。它更具侵袭性，通常与更高的转移率相关。这是我们两篇文章的结论部分，其中探讨了研究 OTSCC 行为和预后的方法、预后标志物，以及预后研究的相关性和未来方向。在这一部分中，我们继续讨论 OTSCC 的组织病理学和分子预后因素，以及血清和唾液生物标志物，并强调需要将 OTSCC 视为口腔癌的高危变异型。最后，我们对 OTSCC 的预后研究的未来方向进行了总结。
