Department of Surgery, Medical College of Wisconsin and Zablocki VA Medical Center, Milwaukee, WI 53295, United States.
Neurosci Lett. 2010 Aug 2;479(3):302-6. doi: 10.1016/j.neulet.2010.05.085.
Restraint stress delays gastric emptying via uncoordinated motility pattern in rats. Central oxytocin has anxiolytic effects and attenuates the hypothalamic-pituitary-adrenal (HPA) axis in response to stress and facilitates stress-induced delayed gastric emptying. However, the role of central oxytocin in regulating gastric motility remains unknown. Postprandial gastric motility was recorded via a strain-gauge transducer, implanted on the antrum in Sprague-Dawley (SD) rats. To investigate whether central and peripheral oxytocin are involved in gastric motility, oxytocin (10 microg) was administered intracerebroventricularly (icv) and intraperitoneally (ip). Central and peripheral oxytocin administration did not affect the postprandial gastric motility under non-stressed conditions. Restraint stress augmented gastric contractions. Central administration of oxytocin, but not peripheral administration, abolished the augmented postprandial gastric contractions induced by restraint stress. Oxytocin facilitates stress-induced delayed gastric emptying via alleviating uncoordinated gastric motility. Oxytocin might be a candidate for the treatment of stress-induced GI motility disorders.
束缚应激通过不协调的运动模式延迟大鼠的胃排空。中枢催产素具有抗焦虑作用，并在应激时减轻下丘脑-垂体-肾上腺（HPA）轴的反应，促进应激诱导的胃排空延迟。然而，中枢催产素在调节胃动力中的作用尚不清楚。通过在 Sprague-Dawley（SD）大鼠的胃窦部植入应变计传感器来记录餐后胃动力。为了研究中枢和外周催产素是否参与胃动力，通过脑室内（icv）和腹腔内（ip）给予催产素（10μg）。在非应激条件下，中枢和外周给予催产素均不影响餐后胃动力。束缚应激增强了胃收缩。中枢给予催产素，但不是外周给予催产素，消除了束缚应激引起的餐后胃收缩的增强。催产素通过缓解不协调的胃动力促进应激诱导的胃排空延迟。催产素可能是治疗应激性胃肠道动力障碍的候选药物。
