预先用咖啡因处理（敏化）可使 6-羟多巴胺损伤大鼠的 D2-多巴胺介导的对侧旋转行为敏感。
Prior treatment (priming) with caffeine sensitizes D2-dopamine-mediated contralateral rotational behavior in 6-hydroxydopamine-lesioned rats.
机构信息
Department of Biology, University of Massachusetts-Boston, Boston, MA 02125, USA.
出版信息
Pharmacology. 2010;86(2):73-8. doi: 10.1159/000315496. Epub 2010 Jul 17.
BACKGROUND/AIMS: In unilaterally dopamine-depleted rats, repeated treatment with dopamine agonists sensitizes contralateral rotational behavior. Since A2a adenosine receptors are co-localized with D2 dopamine receptors in the brain, it was hypothesized that repeated treatment with the adenosine antagonist caffeine could sensitize D2 dopamine-mediated rotational behavior.
METHODS
Rats were unilaterally lesioned with 6-hydroxydopamine (6-OHDA), and pretreated (primed) with 3 injections of caffeine or water. One week later, rats were challenged with the D2 agonist quinpirole (0.25 mg/kg).
RESULTS
6-OHDA rats primed with caffeine (50 mg/kg) displayed contralateral rotational behavior following challenge with quinpirole - an effect not observed with caffeine (10 or 75 mg/kg) or water.
CONCLUSIONS
These results suggest that prior administration of caffeine can sensitize D2 dopamine-mediated rotational behavior in dopamine-depleted rats.
背景/目的：在单侧多巴胺耗竭的大鼠中，重复使用多巴胺激动剂会使对侧旋转行为敏化。由于 A2a 腺苷受体与大脑中的 D2 多巴胺受体共定位，因此假设重复使用腺苷拮抗剂咖啡因可以敏化 D2 多巴胺介导的旋转行为。
方法
大鼠单侧接受 6-羟多巴胺（6-OHDA）损伤，并预先用 3 次咖啡因或水预处理（敏化）。一周后，大鼠接受 D2 激动剂喹吡罗（0.25mg/kg）挑战。
结果
用咖啡因（50mg/kg）敏化的 6-OHDA 大鼠在接受喹吡罗后表现出对侧旋转行为 - 而用咖啡因（10 或 75mg/kg）或水则没有观察到这种作用。
结论
这些结果表明，预先给予咖啡因可以敏化多巴胺耗竭大鼠中 D2 多巴胺介导的旋转行为。
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