Department of Operative Dentistry and Periodontology, University of Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany.
J Mater Sci Mater Med. 2010 Nov;21(11):2971-7. doi: 10.1007/s10856-010-4126-1. Epub 2010 Jul 17.
This study investigated the antibacterial effect of a resin composite matrix with or without incorporated triclosan (0.3 wt%) on Streptococcus mutans, Actinomyces viscosus and Lactobacillus casei. In the quantitative assay, bacterial suspensions were filled into 20-μl cavities within temporary restorative resins. After 0, 4, 8, 12, 24 and 48 h of incubation, the suspensions were removed from the restoratives and the numbers of viable bacteria were determined. Bacterial suspensions incubated without restoratives served as the controls. Ten replicates were carried out for each experiment. The resin composite containing triclosan demonstrated variable degrees of antibacterial activity against the microorganisms, revealing a significant inhibitory effect on S. mutans within 12 h compared to the control. The viable counts of A. viscosus significantly decreased after 24 h. A significant reduction of L. casei was observed after 48 h. The unloaded resin composite did not reveal a marked antibacterial effect. The resin composite loaded with triclosan might be beneficial in preventing cavity contamination and minimizing the risk of pulpal irritation in the short-term.
本研究调查了含有或不含有三氯生（0.3wt%）的树脂复合基质对变形链球菌、粘性放线菌和干酪乳杆菌的抗菌效果。在定量分析中，将细菌悬浮液填充到临时修复树脂的 20μl 腔中。孵育 0、4、8、12、24 和 48 h 后，从修复体中取出悬浮液，并确定活菌数。未用修复体孵育的细菌悬浮液作为对照。每个实验进行了 10 次重复。含有三氯生的树脂复合材料对这些微生物表现出不同程度的抗菌活性，与对照组相比，在 12 h 内对变形链球菌表现出显著的抑制作用。24 h 后，粘性放线菌的活菌数显著减少。48 h 后，干酪乳杆菌的数量明显减少。未负载三氯生的树脂复合材料没有明显的抗菌作用。负载三氯生的树脂复合材料可能有助于防止腔室污染，并在短期内最大限度地降低牙髓刺激的风险。
