Department of Pediatrics, Triemli Hospital Zurich, Birmensdorferstrasse 497, Zurich, Switzerland.
Pediatr Nephrol. 2010 Dec;25(12):2535-8. doi: 10.1007/s00467-010-1599-6. Epub 2010 Jul 18.
Clinical gout has rarely been described after pediatric renal transplantation (RTx), although asymptomatic hyperuricemia is common in these patients. We describe three male pediatric patients who presented with gouty arthritis 7-8.5 years following RTx. Since receiving allopurinol, all patients had been free of gouty symptoms. To prevent severe bone marrow depletion, the dosage of azathioprine, an immunosupressant drug, was reduced by 50% to prevent interaction with allopurinol. Because atypical presentation of gout can occur, a high index of suspicion is needed to allow appropriate diagnosis of this disease in patients with skeletal pain after RTx.
儿科肾移植（RTx）后很少有临床痛风的描述，尽管这些患者常有无症状性高尿酸血症。我们描述了 3 例男性儿科患者，他们在 RTx 后 7-8.5 年出现痛风性关节炎。自从使用别嘌醇后，所有患者的痛风症状均消失。为了防止严重的骨髓耗竭，免疫抑制剂药物硫唑嘌呤的剂量减少了 50%，以防止与别嘌醇相互作用。由于痛风的表现可能不典型，因此对于 RTx 后出现骨骼疼痛的患者，需要高度怀疑该病，以便做出适当的诊断。
