过敏性哮喘患者支气管肺泡灌洗液中组胺水平升高与气道阻塞增加有关。

Elevated bronchoalveolar lavage fluid histamine levels in allergic asthmatics are associated with increased airway obstruction.

作者信息

Jarjour N N, Calhoun W J, Schwartz L B, Busse W W

机构信息

Department of Medicine, School of Medicine, University of Wisconsin, Madison.

出版信息

Am Rev Respir Dis. 1991 Jul;144(1):83-7. doi: 10.1164/ajrccm/144.1.83.

DOI:10.1164/ajrccm/144.1.83

PMID:2064143

Abstract

Bronchoalveolar lavage (BAL) fluid was evaluated for histamine and tryptase levels in 61 samples (46 samples from 24 atopic asthmatics, seven samples from seven patients with allergic rhinitis, and eight samples from eight normal volunteers). Asthmatics and patients with allergic rhinitis had significantly higher BAL histamine than did normal subjects (169 +/- 22, 141 +/- 23, 42 +/- 6 pg/ml, respectively; p less than 0.05, both comparisons). BAL fluid tryptase levels were also higher in asthmatics and patients with allergic rhinitis than in normal subjects (0.36 +/- 0.03, 0.38 +/- 0.05, 0.23 +/- 0.04 ng/ml, respectively; p less than 0.05, both comparisons); however, levels of tryptase and histamine in BAL were not correlated (r = -0.03 in the group as a whole, r = -0.12 in the asthmatic group). BAL concentration of histamine correlated inversely with FEV1 percent predicted in the asthmatic group (r = -0.44, p less than 0.005). Asthmatics with high BAL fluid histamine (greater than or equal to 100 pg/ml, n = 23) had lower FEV1 percent predicted (80 +/- 3% versus 96 +/- 3%, p = 0.0005), lower FEV1/FVC ratio (72 +/- 1% versus 77 +/- 2%, p less than 0.05), higher percentage of BAL eosinophils (2.2 +/- 0.4% versus 0.6 +/- 0.1%, p less than 0.002), and greater airway responsiveness (lower PD20 [13.1 +/- 3.4 versus 41.5 +/- 13.7 cumulative breath units, p less than 0.05]) compared with asthmatics with low BAL fluid histamine (less than 100 pg/ml, n = 23).(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

对61份样本（24例特应性哮喘患者的46份样本、7例变应性鼻炎患者的7份样本和8名正常志愿者的8份样本）的支气管肺泡灌洗（BAL）液进行了组胺和类胰蛋白酶水平评估。哮喘患者和变应性鼻炎患者的BAL组胺水平显著高于正常受试者（分别为169±22、141±23、42±6 pg/ml；两组比较，p均<0.05）。哮喘患者和变应性鼻炎患者的BAL液类胰蛋白酶水平也高于正常受试者（分别为0.36±0.03、0.38±0.05、0.23±0.04 ng/ml；两组比较，p均<0.05）；然而，BAL中类胰蛋白酶和组胺水平不相关（整个组r = -0.03，哮喘组r = -0.12）。哮喘组中BAL组胺浓度与预测的FEV1百分比呈负相关（r = -0.44，p<0.005）。BAL液组胺水平高（≥100 pg/ml，n = 23）的哮喘患者预测的FEV1百分比更低（80±3%对96±3%，p = 0.0005），FEV1/FVC比值更低（72±1%对77±2%，p<0.05），BAL嗜酸性粒细胞百分比更高（2.2±0.4%对0.6±0.1%，p<0.002），气道反应性更强（更低的PD20[13.1±3.4对41.5±13.7累积呼吸单位，p<0.05]），与BAL液组胺水平低（<100 pg/ml，n = 23）的哮喘患者相比。（摘要截断于250字）