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脉冲磁场对疼痛处理的剂量依赖性效应的证据。

Evidence for a dose-dependent effect of pulsed magnetic fields on pain processing.

机构信息

Imaging Program, Lawson Health Research Institute, London, ON, Canada.

出版信息

Neurosci Lett. 2010 Sep 27;482(2):160-2. doi: 10.1016/j.neulet.2010.07.024. Epub 2010 Jul 17.

DOI:10.1016/j.neulet.2010.07.024
PMID:20643187
Abstract

Functional magnetic resonance imaging (fMRI) was used to investigate the dose-response relationship (sham, 100, 200, 1000 microT) between a pulsed extremely low frequency magnetic field (ELFMF) and acute thermal pain on the dominant right hand. Forty-seven participants were recruited, and pulsed ELFMF was applied through the MRI gradient system using a novel technique. Regions of interest (ROIs) matching those of previous studies were examined for a potential dose response. Significant correlations between applied field strength and change in BOLD activity were found in the anterior cingulate and the ipsilateral insula, indicating that there might be either a dose response or a threshold effect of the ELFMF.

摘要

功能性磁共振成像(fMRI)用于研究脉冲极低频磁场(ELFMF)与右手急性热痛之间的剂量反应关系(假刺激、100、200、1000 微特斯拉)。招募了 47 名参与者,并使用一种新的技术通过 MRI 梯度系统应用脉冲 ELFMF。检查了与先前研究相匹配的感兴趣区域(ROI),以研究潜在的剂量反应。在前扣带和同侧脑岛中发现了施加场强与 BOLD 活性变化之间的显著相关性,这表明 ELFMF 可能存在剂量反应或阈值效应。

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