Neuropsychiatric Research Laboratory, Department of Psychiatry, Heinrich-Heine University Duesseldorf, Germany.
Int J Psychophysiol. 2010 Jan;75(1):16-24. doi: 10.1016/j.ijpsycho.2009.10.008. Epub 2009 Oct 12.
A painful experience is modified by processes like habituation/antinociception or sensitization. Altered habituation may be one characteristic of chronic pain syndromes. In the present study we sought to investigate the functional magnetic resonance imaging (fMRI) blood oxygen level dependent (BOLD) correlate of rapid habituation to pain using simultaneous single trial electrodermal activity (EDA)/fMRI measurements. A total of N=32 healthy subjects have been investigated. Subjects received painful laser stimulation of the left hand. The fMRI BOLD response was measured simultaneously with continuous EDA recordings. Single trial EDA responses to laser stimulation habituated over time with substantial subject-to-subject differences in the degree and speed of habituation. fMRI BOLD habituation was assessed by contrasting the first half of the experiment against the second half and was found in primary and secondary somatosensory cortices, the insula and the anterior cingulate cortex (ACC). We hypothesized that single trial EDA habituation would reflect BOLD habituation which was investigated separately in subjects with 'faster' (N=15) and 'slower' (N=14) EDA habituation. Significant habituation of the BOLD signal was only found in subjects with 'faster' EDA habituation that was accompanied by a signal increase in the rostral ACC and the periaqueductal grey. Furthermore, subjects with faster EDA habituation provided lower pain ratings. Therefore the EDA habituation profile to painful stimulation may constitute a pain-related (endo)phenotype and may be an informative additional endpoint measure in fMR-imaging of pain, especially when people suffering from chronic pain states in which pain processing is often altered are studied.
疼痛体验会通过习惯化/抗伤害或敏化等过程进行修饰。习惯化改变可能是慢性疼痛综合征的一个特征。在本研究中，我们试图使用同时进行的单次试验皮肤电活动 (EDA)/fMRI 测量来研究对疼痛的快速习惯化的功能磁共振成像 (fMRI) 血氧水平依赖 (BOLD) 相关性。共对 32 名健康受试者进行了研究。受试者接受左手的疼痛激光刺激。同时测量 fMRI BOLD 对 EDA 记录的反应。随着时间的推移，单次 EDA 反应对激光刺激的习惯化逐渐增强，习惯化的程度和速度在受试者之间存在很大差异。通过对比实验的前半部分和后半部分来评估 fMRI BOLD 习惯化，在前侧感觉皮质、岛叶和前扣带皮质 (ACC) 中发现了习惯化。我们假设单次 EDA 习惯化将反映 BOLD 习惯化，分别在习惯化“更快”（N=15）和“更慢”（N=14）的受试者中进行研究。仅在 EDA 习惯化“更快”的受试者中发现 BOLD 信号的显著习惯化，同时伴随着前扣带皮质和导水管周围灰质的信号增加。此外，习惯化“更快”的受试者的疼痛评分较低。因此，对疼痛刺激的 EDA 习惯化特征可能构成与疼痛相关的（内）表型，并且可能是疼痛 fMRI 研究中的一个有用的附加终点测量指标，特别是在研究患有疼痛处理经常改变的慢性疼痛状态的人群时。
