妥瑞氏症：基因表现作为寻找药物标的的工具。
Tourette syndrome: gene expression as a tool to discover drug targets.
机构信息
Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and Department of Neurology, University of California at Davis, Sacramento, California 95817, USA.
出版信息
Neurotherapeutics. 2010 Jul;7(3):302-6. doi: 10.1016/j.nurt.2010.05.007.
Abstract
Gene expression microarrays are a high-throughput, cost-effective method for measuring the expression of all genes in a sample. By comparing the expression patterns of healthy controls to diseased subjects, the genetic regulatory pathways underlying and affected by the disease can be elucidated. Furthermore, dysregulated genes are possible candidates for pharmaceutical therapy. Here, we consider the possibility of applying this approach to Tourette syndrome. We also review current theories of Tourette syndrome etiology and pharmacology.
摘要
基因表达微阵列是一种高通量、具有成本效益的方法，可用于测量样本中所有基因的表达。通过将健康对照与患病受试者的表达模式进行比较，可以阐明疾病潜在的和受影响的遗传调控途径。此外，失调的基因可能是药物治疗的候选者。在这里，我们考虑将这种方法应用于妥瑞氏综合征。我们还回顾了妥瑞氏综合征病因学和药理学的当前理论。
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