Department of Urology, CHA Bundang Medical Center, CHA University, Seongnam, Seoul, Korea.
J Urol. 2010 Sep;184(3):1057-63. doi: 10.1016/j.juro.2010.04.079.
To our knowledge the effects of preoperative kidney volume in living donors on the post-donation change in size and function of the remaining kidney have not been investigated. We studied the association between preoperative kidney volume, and volume change and delayed kidney function recovery in donors.
From 2007 to 2008 we investigated 222 living donors. Kidney volume before and 6 months after surgery was estimated using the voxel count method. We analyzed correlations of kidney volume with patient characteristics, kidney function and actual kidney weight. To identify predictors of the volume increase of the remaining kidney and predictors of delayed kidney function recovery we performed regression analysis.
Mean +/- SD total kidney volume was 311.9 +/- 50.6 cc and it correlated with weight, body surface area and kidney function (p <0.001). The mean volume increase in the remaining kidney was 27.6% +/- 9.7% (range 4.5% to 66.1%). Younger age (p <0.001) and lower preoperative volume of the remaining kidney (p = 0.019) were significant predictors of a greater increase in kidney volume on multiple linear regression analysis. Older age (OR 1.07, p <0.001), higher body mass index (OR 1.20, p = 0.008), lower preoperative kidney volume of the remaining kidney (OR 0.98, p = 0.003) and a lower preoperative diethylenetetramine pentaacetic acid glomerular filtration rate in the remaining kidney (OR 0.95, p = 0.017) were significant predictors of delayed kidney function recovery on multiple regression analysis.
Kidney volume measured by the voxel count method was accurate and correlated with kidney function. Preoperative kidney volume is an independent predictor of the volume increase and delayed kidney function recovery in donors that could be used clinically.
据我们所知，术前供体肾脏体积对捐献后剩余肾脏大小和功能的变化影响尚未得到研究。我们研究了术前肾脏体积与供体中体积变化和延迟肾功能恢复之间的关系。
2007 年至 2008 年，我们调查了 222 名活体供体。使用体素计数法估计手术前后的肾脏体积。我们分析了肾脏体积与患者特征、肾功能和实际肾脏重量的相关性。为了确定剩余肾脏体积增加的预测因素和肾功能恢复延迟的预测因素，我们进行了回归分析。
平均+/-SD 总肾脏体积为 311.9+/-50.6cc，与体重、体表面积和肾功能相关（p<0.001）。剩余肾脏的平均体积增加为 27.6%+/-9.7%（范围为 4.5%至 66.1%）。年龄较小（p<0.001）和术前剩余肾脏体积较小（p=0.019）是多线性回归分析中肾脏体积增加更大的显著预测因素。年龄较大（OR 1.07，p<0.001）、体质量指数较高（OR 1.20，p=0.008）、术前剩余肾脏体积较小（OR 0.98，p=0.003）和术前剩余肾脏二乙三胺五乙酸肾小球滤过率较低（OR 0.95，p=0.017）是多回归分析中肾功能恢复延迟的显著预测因素。
体素计数法测量的肾脏体积准确，与肾功能相关。术前肾脏体积是供体中体积增加和延迟肾功能恢复的独立预测因素，可在临床上使用。
