关节形状与骨关节炎发展的关系。
Relationship between joint shape and the development of osteoarthritis.
机构信息
University of California, San Francisco, USA.
出版信息
Curr Opin Rheumatol. 2010 Sep;22(5):538-43. doi: 10.1097/BOR.0b013e32833d20ae.
Abstract
PURPOSE OF REVIEW
To present an updated summary of the relationship between joint shape and the development of osteoarthritis, with a particular focus on osteoarthritis of the hip.
RECENT FINDINGS
Osteoarthritis of the hip is highly heritable, with a genetic contribution estimated at 60%. Among the genes that have been linked to this disease are several that are involved in the development and maintenance of joint shape, including members of the Wingless (Wnt) and the bone morphogenetic protein (BMP) family. Several features of hip joint architecture, such as acetabular dysplasia, pistol grip deformity, wide femoral neck, altered femoral neck-shaft angle, appear to play an important role in the pathogenesis of osteoarthritis and may predate the development of osteoarthritis by decades.
SUMMARY
Gene-environment interactions play a crucial role in the development of osteoarthritis. The architecture of joint shape is determined by a complex sequence spanning embryonic, childhood, and adult life and contributes to the pathogenesis of osteoarthritis.
摘要
目的综述
介绍关节形态与骨关节炎发展之间关系的最新研究进展，重点关注髋关节骨关节炎。
最新发现
髋关节骨关节炎具有高度遗传性，遗传因素的贡献估计为 60%。与这种疾病相关的基因包括几个参与关节形态发育和维持的基因，包括 Wingless（Wnt）和骨形态发生蛋白（BMP）家族的成员。髋关节结构的几个特征，如髋臼发育不良、手枪柄畸形、股骨颈增宽、股骨颈干角改变，似乎在骨关节炎的发病机制中起重要作用，并且可能在骨关节炎发病前几十年就存在。
总结
基因-环境相互作用在骨关节炎的发展中起着关键作用。关节形态的结构由跨越胚胎期、儿童期和成年期的复杂序列决定，并有助于骨关节炎的发病机制。
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