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钳夹畸形不会导致髋关节骨关节炎,而髋臼发育不良会导致:全国前瞻性队列研究(CHECK)中的髋臼覆盖和骨关节炎发展。

Pincer deformity does not lead to osteoarthritis of the hip whereas acetabular dysplasia does: acetabular coverage and development of osteoarthritis in a nationwide prospective cohort study (CHECK).

机构信息

Department of Orthopaedics, Erasmus MC University Medical Centre, Rotterdam, The Netherlands.

出版信息

Osteoarthritis Cartilage. 2013 Oct;21(10):1514-21. doi: 10.1016/j.joca.2013.07.004. Epub 2013 Jul 9.

Abstract

OBJECTIVE

Determining the relation between acetabular coverage, especially overcoverage which may lead to pincer impingement, and development of osteoarthritis (OA) of the hip.

DESIGN

From a prospective cohort study of 1,002 individuals with symptoms of early OA (Cohort Hip and Cohort Knee, CHECK), 720 participants were included. Standardized anteroposterior pelvic radiographs and false profile lateral radiographs were obtained at baseline and 5 years follow-up. Acetabular undercoverage (mild dysplasia) and overcoverage (pincer deformity) were measured by a centre edge angle of <25° and >40° respectively in both radiographic views. The strength of association between those parameters at baseline and development of incident OA (Kellgren and Lawrence (K&L) grade >2 or total hip replacement), or joint space narrowing within 5 years was expressed in odds ratio (OR) adjusted for K&L grade, age, body mass index (BMI), and sex using generalized estimating equations.

RESULTS

At baseline, 76% of the included hips had no signs of radiographic OA (K&L = 0) whereas 24% had doubtful OA (K&L = 1). Within 5 years, 7.0% developed incident OA. Acetabular dysplasia was significantly associated with development of incident OA with ORs between 2.62 (95% confidence interval (CI) 1.44-4.77) and 5.45 (95% CI 2.40-12.34), dependent on the radiographic view. A pincer deformity was not associated with any outcome measure, except for a significantly protective effect on incident OA when a pincer deformity was present in both radiographic views OR 0.34 (95% CI 0.13-0.87).

CONCLUSION

Acetabular dysplasia was significantly associated with development of OA. However, a pincer deformity was not associated with OA, and might even have a protective effect on its development, which questions the supposed detrimental effect of pincer impingement.

摘要

目的

确定髋臼覆盖,特别是可能导致钳夹撞击的过覆盖与髋关节骨关节炎(OA)发展之间的关系。

设计

从有早期 OA 症状的 1002 名个体的前瞻性队列研究(髋关节和膝关节队列研究,CHECK)中,纳入了 720 名参与者。在基线和 5 年随访时获得了标准的前后骨盆射线照片和假性侧位侧位射线照片。在两个射线照片视图中,通过中心边缘角<25°和> 40°分别测量髋臼下覆盖(轻度发育不良)和过覆盖(钳夹畸形)。在基线时那些参数与新发生的 OA(Kellgren 和 Lawrence(K&L)分级> 2 或全髋关节置换)或 5 年内关节间隙狭窄的相关性,使用广义估计方程,通过 K&L 分级、年龄、体重指数(BMI)和性别调整比值比(OR)来表示。

结果

在基线时,76%的纳入髋关节没有放射学 OA 的迹象(K&L=0),而 24%有可疑的 OA(K&L=1)。在 5 年内,7.0%的人发生新的 OA。髋臼发育不良与新发生的 OA 显著相关,OR 值在 2.62(95%置信区间(CI)1.44-4.77)和 5.45(95% CI 2.40-12.34)之间,这取决于射线照片视图。钳夹畸形与任何结局测量均无关,除了在两个射线照片视图中存在钳夹畸形时对新发生的 OA 有显著的保护作用,OR 0.34(95% CI 0.13-0.87)。

结论

髋臼发育不良与 OA 的发展显著相关。然而,钳夹畸形与 OA 无关,甚至可能对其发展有保护作用,这对钳夹撞击的有害作用提出了质疑。

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