Beth Israel Medical Center, 10 Union Square East, New York, NY 10016, USA.
Expert Rev Anticancer Ther. 2010 Jul;10(7):1069-76. doi: 10.1586/era.10.36.
High-risk prostate cancer poses a significant challenge to the treating physician and much debate exists regarding the ideal treatment approach. The purpose of this article is to enable physicians to identify patients with high-risk localized prostate cancer and evaluate whether monotherapy is sufficient for these patients. We review the current data on use of surgery, radiation therapy and hormonal therapy independently and in combination. We also discuss emerging therapeutics for high-risk disease including neoadjuvant chemotherapy and protocols under current and future investigation.
高危前列腺癌给治疗医生带来了巨大的挑战,对于理想的治疗方法存在着广泛的争论。本文的目的是使医生能够识别出患有高危局限性前列腺癌的患者,并评估单药治疗是否足以满足这些患者的需求。我们回顾了手术、放疗和激素治疗单独和联合应用的现有数据。我们还讨论了高危疾病的新兴治疗方法,包括新辅助化疗和当前及未来研究中的方案。