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当代高危局限性前列腺癌的治疗方法。

Contemporary treatment of high-risk localized prostate cancer.

机构信息

Beth Israel Medical Center, 10 Union Square East, New York, NY 10016, USA.

出版信息

Expert Rev Anticancer Ther. 2010 Jul;10(7):1069-76. doi: 10.1586/era.10.36.

DOI:10.1586/era.10.36
PMID:20645696
Abstract

High-risk prostate cancer poses a significant challenge to the treating physician and much debate exists regarding the ideal treatment approach. The purpose of this article is to enable physicians to identify patients with high-risk localized prostate cancer and evaluate whether monotherapy is sufficient for these patients. We review the current data on use of surgery, radiation therapy and hormonal therapy independently and in combination. We also discuss emerging therapeutics for high-risk disease including neoadjuvant chemotherapy and protocols under current and future investigation.

摘要

高危前列腺癌给治疗医生带来了巨大的挑战,对于理想的治疗方法存在着广泛的争论。本文的目的是使医生能够识别出患有高危局限性前列腺癌的患者,并评估单药治疗是否足以满足这些患者的需求。我们回顾了手术、放疗和激素治疗单独和联合应用的现有数据。我们还讨论了高危疾病的新兴治疗方法,包括新辅助化疗和当前及未来研究中的方案。

相似文献

1
Contemporary treatment of high-risk localized prostate cancer.当代高危局限性前列腺癌的治疗方法。
Expert Rev Anticancer Ther. 2010 Jul;10(7):1069-76. doi: 10.1586/era.10.36.
2
Long-term outcome of patients with prostate cancer and pathologic seminal vesicle invasion (pT3b): effect of adjuvant radiotherapy.前列腺癌伴病理证实精囊侵犯(pT3b)患者的长期预后:辅助放疗的效果
Urology. 2004 Jul;64(1):84-9. doi: 10.1016/j.urology.2004.02.004.
3
[Place of surgery in high-risk tumours of the prostate].[前列腺高危肿瘤的手术部位]
Cancer Radiother. 2010 Oct;14(6-7):493-9. doi: 10.1016/j.canrad.2010.06.006. Epub 2010 Aug 19.
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[Combination of external irradiation and androgen suppression for prostate cancer: facts and questions].[前列腺癌的外照射与雄激素抑制联合治疗:事实与问题]
Cancer Radiother. 2010 Oct;14(6-7):510-4. doi: 10.1016/j.canrad.2010.07.226. Epub 2010 Aug 21.
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External beam radiation therapy for clinically localized prostate cancer: when and how we optimize with concurrent hormonal deprivation.临床局限性前列腺癌的外照射放疗:何时以及如何通过同步激素剥夺进行优化。
Arch Esp Urol. 2011 Oct;64(8):858-64.
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Five-year outcomes after neoadjuvant chemotherapy and conformal radiotherapy in patients with high-risk localized prostate cancer.高危局限性前列腺癌患者新辅助化疗和适形放疗后的五年预后
Urology. 2004 Jul;64(1):90-4. doi: 10.1016/j.urology.2004.03.006.
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[What is the best strategy of hormonal therapy in the treatment of locally advanced prostate cancer?].[激素疗法治疗局部晚期前列腺癌的最佳策略是什么?]
Hinyokika Kiyo. 2006 Jun;52(6):473-7.
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Neoadjuvant hormonal therapy in the management of prostate cancer: a surgical and radiation therapy review.前列腺癌管理中的新辅助激素治疗:外科手术与放射治疗综述
Tech Urol. 1996 Winter;2(4):194-206.
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Adjuvant and salvage treatment options for patients with high-risk prostate cancer treated with radical prostatectomy.接受根治性前列腺切除术的高危前列腺癌患者的辅助治疗和挽救治疗选择。
Prostate Cancer Prostatic Dis. 2007;10(2):119-26. doi: 10.1038/sj.pcan.4500947. Epub 2007 Feb 20.
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[Radiotherapy combined with hormonal therapy as treatment method in patients with prostate cancer: still more questions than answers].[放射治疗联合激素治疗作为前列腺癌患者的治疗方法:问题仍多于答案]
Przegl Lek. 2005;62(12):1455-9.

引用本文的文献

1
Outcomes of Gleason Score ≤ 8 among high risk prostate cancer treated with 125I low dose rate brachytherapy based multimodal therapy.低剂量率 125I 近距离放疗为基础的多模态治疗高危前列腺癌 Gleason 评分≤8 患者的结果。
Yonsei Med J. 2013 Sep;54(5):1207-13. doi: 10.3349/ymj.2013.54.5.1207.