使君子乙醇提取物对大鼠的抗炎作用。

Anti-inflammatory effect of Stereospermum suaveolens ethanol extract in rats.

机构信息

Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.

出版信息

Pharm Biol. 2010 Mar;48(3):318-23. doi: 10.3109/13880200903127383.

DOI:10.3109/13880200903127383

PMID:20645819

Abstract

The anti-inflammatory effect of the ethanol extract of Stereospermum suaveolens (Roxb.) DC (Bignoniaceae) bark given orally at the dose of 200 and 400 mg/kg body weight was studied in rats using the carrageenan-, dextran-, and histamine-induced hind paw edema, and cotton pellet-induced granuloma formation models. Indomethcin at the dose of 10 mg/kg body weight was used as a standard drug. The extract (400 mg/kg body weight per os) showed maximum inhibition of edema 64.6, 53.48, and 50.06% at the end of 3 h with carrageenan-, dextran-, and histamine-induced rat paw edema, respectively. The extract (400 mg/kg) exhibited significant reduction (34.77%) in granuloma weight in the cotton pellet-induced granuloma model. From these results it could be concluded that, the ethanol extract of Stereospermum suaveolens possesses maximum anti-inflammatory activity in a dose-dependent manner, in various experimental models.

摘要

采用角叉菜胶、葡聚糖和组胺致大鼠后足肿胀及棉垫肉芽肿形成模型，研究了口服给予剂量为 200 和 400mg/kg 体重的 Stereospermum suaveolens（Roxb.）DC（紫葳科）树皮乙醇提取物的抗炎作用。以吲哚美辛（剂量为 10mg/kg 体重）作为标准药物。提取物（口服 400mg/kg 体重）在 3 小时末分别对角叉菜胶、葡聚糖和组胺诱导的大鼠后足肿胀的最大抑制率为 64.6%、53.48%和 50.06%。提取物（400mg/kg）在棉垫肉芽肿模型中显著减少肉芽肿重量（34.77%）。从这些结果可以得出结论，Stereospermum suaveolens 的乙醇提取物在各种实验模型中具有最大的剂量依赖性抗炎活性。