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[异他林和普萘洛尔对乳腺分泌细胞膜电位的影响]

[Effect of isadrine and propranolol on the membrane potential of mammary secretory cells].

作者信息

Grachev I I, Toljunov Iu A, Markov A G

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1978 Mar;64(3):309-14.

PMID:206473
Abstract

1.10(-7)--1.10(-5) g/ml of isadrine induced a 2-phase hyperpolarization changes of MP of the secretory cell. Propranolol (1.10(-6) g/ml) decreased the amplitude of hyperpolarization response of the MP to oxytocin by 36%; 1.10(-9)--1.10(-8) g/ml of isadrine induced a 42% and 53% decrease respectively, and 1.10(-7)--1.10(-5) g/ml blocked the response of secretory cells to oxytocin. The data obtained suggest that catecholamines can effect the MP by means of interaction with beta-adrenoreceptors of mammary secretory cells.

摘要

1.10(-7)--1.10(-5)克/毫升的异他林可诱导分泌细胞的膜电位出现两阶段超极化变化。普萘洛尔(1.10(-6)克/毫升)使膜电位对催产素的超极化反应幅度降低了36%;1.10(-9)--1.10(-8)克/毫升的异他林分别使超极化反应降低了42%和53%,而1.10(-7)--1.10(-5)克/毫升则阻断了分泌细胞对催产素的反应。所获得的数据表明,儿茶酚胺可通过与乳腺分泌细胞的β-肾上腺素能受体相互作用来影响膜电位。

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