Institute of Medical Engineering, Graz University of Technology, Kronesgasse 5, A-8010 Graz, Austria.
Physiol Meas. 2010 Aug;31(8):S135-45. doi: 10.1088/0967-3334/31/8/S11. Epub 2010 Jul 21.
Magnetic induction tomography aims to reconstruct the electrical conductivity distribution of the human body using non-contact measurements. The potential of the method has been demonstrated by various simulation studies and a number of phantom experiments. These studies have all relied on models having isotropic distributions of conductivity, although the human body has a highly heterogeneous structure with partially anisotropic properties. Therefore, whether the conventional modeling approaches used so far are appropriate for clinical applications or not is still an open question. To investigate the problem, we performed a simulation study to investigate the feasibility of (1) imaging anisotropic perturbations within an isotropic medium and (2) imaging isotropic perturbations inside a partially anisotropic background. The first is the case for the imaging of anomalies that have anisotropic characteristics and the latter is the case e.g. in lung imaging where an anisotropic skeletal muscle tissue surrounds the lungs and the rib cage. An anisotropic solver based on the singular value decomposition was used to attain conductivity tensor images to be compared with the ones obtained from isotropic solvers. The results indicate the importance of anisotropic modeling in order to obtain satisfactory reconstructions, especially for the imaging of the anisotropic anomalies, and address the resolvability of the conductivity tensor components.
磁感应断层成像旨在通过非接触测量来重建人体的电导率分布。该方法的潜力已通过各种模拟研究和一些体模实验得到证明。这些研究都依赖于具有各向同性电导率分布的模型,尽管人体具有高度各向异性的结构和部分各向异性的特性。因此,迄今为止使用的常规建模方法是否适用于临床应用仍然是一个悬而未决的问题。为了研究这个问题,我们进行了一项模拟研究,以调查(1)在各向同性介质中成像各向异性扰动,以及(2)在部分各向异性背景中成像各向同性扰动的可行性。前者是对具有各向异性特征的异常进行成像的情况,后者是例如在肺部成像中,各向异性的骨骼肌组织环绕着肺部和肋骨。使用基于奇异值分解的各向异性求解器来获得电导率张量图像,以便与各向同性求解器获得的图像进行比较。结果表明,为了获得令人满意的重建,特别是对各向异性异常的成像,进行各向异性建模是很重要的,并解决了电导率张量分量的可分辨性问题。