Stalling in mitosis and releasing the apoptotic brake.
作者信息
Kurokawa Manabu, Kornbluth Sally
机构信息
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA.
出版信息
EMBO J. 2010 Jul 21;29(14):2255-7. doi: 10.1038/emboj.2010.150.
Abstract
摘要
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本文引用的文献
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Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest.
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Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis.
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