Institute of Pharmacology, University of Bern, Bern, Switzerland.
Swiss Med Wkly. 2010 Jul 20;140:w13042. doi: 10.4414/smw.2010.13042. eCollection 2010.
The immune system is composed of an enormous variety of cells and molecules that generate a collective and coordinated response on exposure to foreign antigens, called the immune response. Within the immune response, endo-lysosomal proteases play a key role. In this review we cover specific roles of cathepsins in innate and adaptive immunity, as well as their implication in the pathogenesis of several diseases.
免疫系统由大量的细胞和分子组成，这些细胞和分子在接触到外来抗原时会产生集体协调的反应，称为免疫反应。在免疫反应中，内体溶酶体蛋白酶起着关键作用。在这篇综述中，我们介绍了组织蛋白酶在先天免疫和适应性免疫中的特定作用，以及它们在几种疾病发病机制中的作用。
