Alcauter-Solórzano Sarael, Pasaye-Alcaraz Erick H, Alvarado-Alanis Patricia, Fermín-Delgado Rafael O, Alonso-Vilatela M Elisa, Salgado-Lujambio Perla, Barrios Fernando A
Posgrado en Ciencias Biomédicas, Universidad Nacional Autónoma de México, Querétaro, QRO, México.
Rev Neurol. 2010 Aug 16;51(4):208-12.
Huntington's disease is an hereditary autosomic-dominant neurodegenerative disorder, characterized by motor, cognitive and psychiatric symptoms.
To quantify differences in N-acetylaspartate, creatine and choline in caudate nucleus, putamen and occipital cortex of patients with Huntington's disease, symptomatics and asymptomatics.
Hydrogen magnetic resonance spectroscopy was performed with a 3 T scanner in 10 Huntington's disease gene-tested subjects, included in three groups: negative (control), positive symptomatics and positive asymptomatics. Data was quantified with LCModel and analyzed with ANOVA and Fisher tests.
Symptomatic patients showed decreased creatine and N-acetylaspartate in the three regions, and decreased choline only in putamen (p < 0.05). Choline difference was found between symptomatics and asymptomatics in the caudate nucleus (p < 0.05).
Results may reflect neuronal dysfunction and suggest that creatine and choline may serve as markers for Huntington's disease progression.
亨廷顿舞蹈症是一种常染色体显性遗传的神经退行性疾病，其特征为运动、认知和精神症状。
量化亨廷顿舞蹈症患者（有症状和无症状）尾状核、壳核及枕叶皮质中N - 乙酰天门冬氨酸、肌酸和胆碱的差异。
使用3T扫描仪对10名经亨廷顿舞蹈症基因检测的受试者进行氢磁共振波谱分析，这些受试者分为三组：阴性（对照组）、阳性有症状组和阳性无症状组。数据用LCModel进行量化，并通过方差分析和费舍尔检验进行分析。
有症状患者在上述三个区域的肌酸和N - 乙酰天门冬氨酸均降低，仅壳核中的胆碱降低（p < 0.05）。尾状核中有症状组与无症状组之间胆碱存在差异（p < 0.05）。
结果可能反映神经元功能障碍，并表明肌酸和胆碱可能作为亨廷顿舞蹈症进展的标志物。
